Radiation Doses and Fractionation Schedules in Non-low Risk Ductal Carcinoma In Situ (DCIS) of the Breast

NAUnknownINTERVENTIONAL
Enrollment

1,608

Participants

Timeline

Start Date

June 30, 2007

Primary Completion Date

June 30, 2024

Study Completion Date

June 30, 2024

Conditions
Carcinoma, Ductal, Breast
Interventions
RADIATION

Standard WB fractionation

A total dose of 50 Gy in 25 fractions in 2-Gy daily fractions, 5 fractions per week (at least 9 fractions per fortnight).

RADIATION

Shorter WB fractionation

A total dose of 42.5 Gy in 16 fractions in 2.656-Gy daily fractions, 5 fractions per week (at least 9 fractions per fortnight).

RADIATION

Standard WB fractionation+Boost

"Whole Breast: A total dose of 50 Gy in 25 fractions in 2-Gy daily fractions, 5 fractions per week (at least 9 fractions per fortnight).~Tumour bed: A total dose of 10 Gy in 5 fractions in 2-Gy daily fractions, 5 fractions per week."

RADIATION

Shorter WB fractionation + Boost

"Whole breast: A total dose of 42.5 Gy in 16 fractions in 2.656-Gy daily fractions, 5 fractions per week (at least 9 fractions per fortnight).~Tumour bed: A total dose of 10 Gy in 4 fractions in 2.5-Gy daily fractions, 4 fractions per week."

Trial Locations (120)

1001

Auckland Hospital, Auckland

2065

Royal North Shore Hospital, St Leonards

2145

Westmead Hospital, Wentworthville

2170

Liverpool Hospital, Liverpool

2217

St George Hospital, Kogarah

2298

Calvary Mater Newcastle, Waratah

2560

Campbelltown Hospital, Campbelltown

2650

Riverina Cancer Care Centre, Wagga Wagga

3002

Peter MacCallum Cancer Centre, Melbourne

3084

Austin Hospital, Melbourne

3181

William Buckland Radiotherapy Centre, Alfred Hospital, Melbourne

3204

Waikato Hospital, Hamilton

3220

Barwon Health - Andrew Love Cancer Care Centre, Geelong Hospital, Geelong

4006

Premion - Wesley, Auchenflower

Royal Brisbane and Women's Hospital, Brisbane

4101

Radiation Oncology - Mater Centre, South Brisbane

4102

Princess Alexandra Hospital, Brisbane

4224

Genesis Cancer Care (previously Premion) - Tugun, Tugun

4810

North Queensland Oncology Service, Townsville

5000

Royal Adelaide Hospital, Adelaide

6001

Royal Perth Hospital, Perth

6009

Sir Charles Gardiner Hospital, Nedlands

7000

Royal Hobart Hospital, Hobart

7250

Launceston General Hospital, Launceston

8011

Christchurch Hospital, Christchurch

119074

National University Hospital, Singapore

Unknown

Nepean Cancer Care Centre, Kingswood

Genesis Cancer Care (previously Premion) - Nambour, Nambour

Toowoomba Cancer Research Centre, Toowoomba

Perth Radiation Oncology, Perth

Onze Lieve Vrouw Ziekenhuis, Aalst

ZNA Middelheim, Antwerp

Cliniques Univeritaires St Luc, Brussels

Universitair Zielenhusi, Brussels

Hopital De Jolimont, Haine-Saint-Paul

AZ Groeninghe - Campus Maria's Voorzienigheid, Kortrijk

Algemeen Ziekenhis Sint-Augustinus, Wilrijk

Nova Scotia Cancer Centre, Halifax

Jurvanski Cancer Centre, Hamilton

Notre Dame Hospital, Hearst

BCCA Southern Interior - CAVK, Kelowna

London Regional Cancer Program, London

Saint John Regional Hospital, Miramichi

Leon Richard Oncology Centre, Moncton

Hospital Maisonneuve-Rosemont, Montreal

Lakeridge Health, Oshawa

CHUQ L'Hotel-Dieu de Quebec, Québec

McGill University Department of Oncology, Sainte-Anne-de-Bellevue

Allan Blair Cancer Centre, Saskatoon

Saskatoon Cancer Centre, Saskatoon

Universite de Sherbrooke - CUGH, Sherbrooke

Thunder Bay Regional Health Sciences Centre, Thunder Bay

Odette Cancer Centre, Toronto

Princess Margaret Hospital, Toronto

BCCA Vancouver Centre, Victoria

Vancouver Island Cancer Centre, Victoria

Cancer Care Manitoba, Winnipeg

Chr De Grenoble - La Tronche, Grenoble

Centre Antine Lacassagne, Nice

Cork University Hospital, Cork

University Hospital Galway, Galway

SLRON (St Luke's Rad Onc Network), Rathgar

Centro Di Riferimento Oncologico - Aviano, Aviano

Fondazione Salvatore Maugeri, Pavia

Academisch Medisch Centrum, Amsterdam

Cancer Institute Antoni Van Leeuwenhoekziekenhuis, Amsterdam

Arnhem 'S Radiotherapeutisch Instituut, Arnhem

Reinier de Graaf Groep, Delft

University Medical Centre Groningen, Groningen

Leiden University Medical Centre, Leiden

Maastricht Radiation Oncology Maastro Clinic, Maastricht

Medisch Centrum Haaglanden, Westeinde

ISALA Klinieken, Zwolle

University Hospital Basel, Basel

IOSI, Bellinzona

Inselspital Bern, Bern

Kantonsspital Graubunden, Chur

Kantonsspital Munsterlingen, Münsterlingen

Kantonsspital St. Gallen, Sankt Gallen

Brust-Zentrum Zurich-Seefeld, Zurich

Klinik Hirslanden, Zurich

Gloucestershire Royal & Cheltenham General Hospitals, Cheltenham

Churchill Hospital, Oxford

Pilgram Hospital, Boston

Mount Vernon Cancer Centre, Northwood

Ealing Hospital, Southall

Kings Mill Hospital Nottingham, Sutton in Ashfield

Musgrove Park Hospital, Taunton

Queens Hospital Burton, Burton-on-Trent

University of North Staffordshire, Stoke-on-Trent

Aberdeen Royal Infirmary, Aberdeen

Basildon University Hospital, Basildon

Belfast City Hospital, Belfast

Queen Elizabeth Hospital, Birmingham

Sandwell and West Birmingham Hospitals NHS Trust, Birmingham

Bristol Haematology & Oncology, Bristol

Colchester Hospital, Colchester

Coventry Arden Cancer Centre, Coventry

Royal Derby Hospital, Derby

Dumfries & Galloway Royal Infirmary, Dumfries

Queen Margaret Hospital, Dunfermline

Edinburgh Western General Hospital, Edinburgh

The Beatson West of Scotland Cancer Centre, Glasgow

Royal Surrey County Hospital, Guildford

Ipswich Hospital, Ipswich

Kidderminster Hospital, Kidderminster

Leicester Royal Infirmary, Leicester

Lincoln County Hospital, Lincoln

Imperial College Healthcare Charing Cross, London

James Cook University Hospital, Middlesbrough

Nottingham University Hospitals, Nottingham

Royal Alexandra Hospital, Paisley

Alexandra Hospital, Redditch

Weston Park Hospital, Sheffield

The Shrewsbury and Telford Hospital NHS Trust, Shrewsbury

Southend University Hopstial, Southend

Stafford Hospital, Stafford

Royal Marsden, Sutton

Warwick Hospital, Warwick

New Cross Hospital, Wolverhampton

All Listed Sponsors
collaborator

Breast International Group

OTHER

collaborator

NCIC Clinical Trials Group

NETWORK

collaborator

Cancer Trials Ireland

NETWORK

collaborator

Borstkanker Onderzoek Groep

NETWORK

collaborator

ETOP IBCSG Partners Foundation

NETWORK

collaborator

Scottish Cancer Trials Breast Group

UNKNOWN

collaborator

European Organisation for Research and Treatment of Cancer - EORTC

NETWORK

lead

Trans Tasman Radiation Oncology Group

OTHER