72
Participants
Start Date
September 30, 2006
Primary Completion Date
March 31, 2013
Study Completion Date
March 31, 2013
Clofarabine
Day -6 to Day -3 for Arm 1 = 10 mg/m\^2 intravenous (IV) Daily; Arm 2 = 20 mg/m\^2 IV Daily; Arm 3 = 30 mg/m\^2 IV Daily; Arm 4 = 40 mg/m\^2 IV Daily
Busulfan
"Day -6 to Day -3 for Arm 1: 30 mg/m\^2 IV Daily; Arm 2: 20 mg/m\^2 IV Daily; Arm 3: 10 mg/m\^2 IV Daily; Arm 4: 40 mg/m\^2 IV Daily.~Test dose Day -8 32 mg/ m\^2 IV over 45 min, rest on Day -7."
Fludarabine
Day -6 to Day -3 for Arm 1: 30 mg/m\^2 IV Daily; Arm 2: 20 mg/m\^2 IV Daily; Arm 3: 10 mg/m\^2 IV Daily
Stem Cell Infusion
Day 0 stem cell infusion (Bone marrow or peripheral blood progenitor cells (PBPC))
Thymoglobulin (ATG)
Day -3 to Day -1 at 0.5 mg/kg IV on Day -3; 1.5 mg/kg on Day -2 and 2.0 mg/kg on Day -1.
Filgrastim
Subcutaneous injection daily, starting 1 week after Stem Cell Transplant.
UT MD Anderson Cancer Center, Houston
Genzyme, a Sanofi Company
INDUSTRY
M.D. Anderson Cancer Center
OTHER