A Study to Evaluate the Safety and Efficacy of MabThera (Rituximab) in Combination With Methotrexate (MTX) in Participants With Active Rheumatoid Arthritis Who Failed on Anti-Tumor Necrosis Factor Alpha Therapy

PHASE3CompletedINTERVENTIONAL
Enrollment

520

Participants

Timeline

Start Date

May 31, 2003

Primary Completion Date

January 31, 2005

Study Completion Date

July 31, 2012

Conditions
Rheumatoid Arthritis
Interventions
DRUG

MabThera/Rituxan

1

DRUG

Methotrexate

2

OTHER

Placebo

3

Trial Locations (115)

4

Dublin

1070

Brussels

1200

Brussels

2609

Lillehammer

3004

Drammen

4000

Liège

9000

Ghent

9038

Tromsø

10003

New York

10117

Berlin

11030

Manhasset

11787

Smithtown

12206

Albany

14618

Rochester

16011

Arenzano

16132

Genoa

16635

Duncansville

19140

Philadelphia

19141

Philadelphia

19152

Philadelphia

20157

Milan

21224

Baltimore

25123

Brescia

27710

Durham

27834

Greenville

31059

Toulouse

32806

Orlando

33100

Udine

33334

Fort Lauderdale

33458

Jupiter

33484

Delray Beach

33486

Boca Raton

33773

Largo

34295

Montpellier

35294

Birmingham

37044

Tours

40882

Ratingen

44143

Mayfield

44195

Cleveland

45402

Dayton

46260

Indianapolis

48910

Lansing

49048

Kalamazoo

53717

Madison

53792

Madison

55905

Rochester

56100

Pisa

60612

Chicago

60637

Chicago

63110

St Louis

63141

St Louis

67098

Strasbourg

71103

Shreverport

72205

Little Rock

73103

Oklahoma City

73109

Oklahoma City

74135

Tulsa

75231

Dallas

75246

Dallas

75679

Paris

76031

Rouen

76708

Waco

77074

Houston

79124

Amarillo

83642

Meridian

83702

Boise

83814

Coeur d'Alene

84132

Salt Lake City

85208

Mesa

85253

Paradise Valley

85724

Tucson

90045

Los Angeles

90048

Los Angeles

91105

Pasadena

91786

Upland

92037

La Jolla

92270

Rancho Mirage

92835

Fullerton

93454

Santa Maria

94275

Le Kremlin-Bicêtre

94304

Palo Alto

97080

Würzburg

98101

Seattle

98104

Seattle

99204

Spokane

3109601

Haifa

3339419

Haifa

4941492

Petah Tikva

5262000

Ramat Gan

6423906

Tel Aviv

9112001

Jerusalem

06810

Danbury

46202-5149

Indianapolis

02215

Boston

27599-7600

Chapel Hill

45267-0563

Cincinnati

05401

Burlington

T2N 4Z6

Calgary

T6G 2S2

Edmonton

V5Z 1L7

Vancouver

L8N 2B6

Hamilton

N6A 4V2

London

M4N 3M5

Toronto

M5G 1X5

Toronto

01067

Dresden

04103

Leipzig

Unknown

Cork

1105 AZ

Amsterdam

0370

Oslo

WS11 5XY

Cannock

LS7 4SA

Leeds

E11 1NR

London

M41 5SL

Manchester

CH49 5PE

Metropolitan Borough of Wirral

NE7 7DN

Newcastle upon Tyne

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Biogen

INDUSTRY

lead

Hoffmann-La Roche

INDUSTRY

NCT00468546 - A Study to Evaluate the Safety and Efficacy of MabThera (Rituximab) in Combination With Methotrexate (MTX) in Participants With Active Rheumatoid Arthritis Who Failed on Anti-Tumor Necrosis Factor Alpha Therapy | Biotech Hunter | Biotech Hunter