5
Participants
Start Date
December 31, 2006
Primary Completion Date
November 30, 2011
Study Completion Date
February 28, 2014
Islet transplant
Transplantation of pancreatic islet cells
Antithymocyte globulin
Immunosuppressive that selectively depletes activated T-cells and depletes resting T-cells in a dose-dependent manner.
Basiliximab
Will replace antithymocyte globulin in all islet transplantations after the first one
Lisofylline
An anti-inflammatory that may reduce the rate at which islet cells die.
Sirolimus
Maintenance immunosuppressive therapy
Tacrolimus
Maintenance immunosuppressive therapy
University of Illinois at Chicago, Chicago
University of Miami, Miami
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
National Institute of Allergy and Infectious Diseases (NIAID)
NIH