Phenylephrine in Spinal Anesthesia in Preeclamptic Patients

NACompletedINTERVENTIONAL
Enrollment

110

Participants

Timeline

Start Date

July 31, 2006

Primary Completion Date

December 31, 2016

Study Completion Date

December 31, 2016

Conditions
PreeclampsiaHypotension
Interventions
DRUG

Ephedrine

Ephedrine concentration: 8 mg/mL. The infusion will be initiated immediately after completion of the spinal injection at a rate of 1 mL/min and continued for a minimum of 2 min after which the infusion will be stopped, continued or increased based on the SBP each minute. After each SBP measurement the infusion will be stopped if SBP \> 80% baseline, and the infusion will be continued or restarted if the SBP is approximately equal to 80% baseline. The infusion will be increased by 1 mL/min if the SBP \< 80% baseline. Each time there is hypotension the patient will receive a 1 mL IV bolus of the study solution and the infusion will be increased by 1 mL/min until delivery.

DRUG

Phenylephrine

Phenylephrine concentration: 100 mcg/mL. The infusion will be initiated immediately after completion of the spinal injection at a rate of 1 mL/min and continued for a minimum of 2 min after which the infusion will be stopped, continued or increased based on the SBP each minute. After each SBP measurement the infusion will be stopped if SBP \> 80% baseline, and the infusion will be continued or restarted if the SBP is approximately equal to 80% baseline. The infusion will be increased by 1 mL/min if the SBP \< 80% baseline. Each time there is hypotension the patient will receive a 1 mL IV bolus of the study solution and the infusion will be increased by 1 mL/min until delivery.

Trial Locations (2)

60611

Northwestern Memorial Hospital, Chicago

Northwestern University, Chicago

All Listed Sponsors
lead

Northwestern University

OTHER

NCT00458003 - Phenylephrine in Spinal Anesthesia in Preeclamptic Patients | Biotech Hunter | Biotech Hunter