37
Participants
Start Date
September 30, 2006
Primary Completion Date
May 31, 2012
Study Completion Date
May 31, 2012
Escitalopram
Escitalopram will be administered at a dose of 10 mg daily for 4 weeks. If participants have not achieved response (greater than 50 % improvement in Hamilton Depression Rating Scale) by 4 weeks, the dose will be increased to 20 mg. Remission status is determined after an 8-week trial.
Desipramine
Subsequent to escitalopram trial, non-remitters will be offered pharmacotherapy with desipramine. Desipramine will be initiated at a dose of 50 mg and titrated according to a treatment manual, with monitoring of therapeutic blood levels. Remission status is determined after an 8-week trial.
Columbia University/New York State Psychiatric Institute, New York
National Institute of Mental Health (NIMH)
NIH
New York State Psychiatric Institute
OTHER