89
Participants
Start Date
March 31, 2007
Primary Completion Date
January 31, 2013
Study Completion Date
January 31, 2013
Mecamylamine
A single dose of 10 mg of mecamylamine (via two 5 mg capsules) is given at the start of the mecamylamine arm of the study. This is the only administration of mecamylamine given during the course of the study. Participants' blood pressure and vitals are checked regularly for five hours after drug administration for monitoring and safety assurance.
Varenicline
A single dose of 1 mg of varenicline (via two 0.5 mg capsules) is given at the start of the varenicline arm of the study. This is the only administration of varenicline given during the course of the study. Participants' blood pressure and vitals are checked regularly for five hours after drug administration for monitoring and safety assurance.
Placebo
The placebo contains no active medication. The placebo dose is given via two capsules at the start of the placebo arm of the study. Participants' blood pressure and vitals are checked regularly for five hours after drug administration for monitoring and safety assurance. The placebo has no effects that last for any duration of time.
Freedom Trail Clinic, Massachusetts General Hospital, Boston
National Alliance for Research on Schizophrenia and Depression
OTHER
The Bowman Family Foundation
UNKNOWN
Massachusetts General Hospital
OTHER