35
Participants
Start Date
September 30, 2004
Primary Completion Date
June 30, 2010
Study Completion Date
March 31, 2012
Placebo Comparator: First Intervention (3 weeks)
once daily placebo tablet for 3 weeks followed by: euglycemic clamp procedure; 24 hour Ambulatory Blood Pressure; Oral Glucose tolerance Test; serum collection; 24 hour urine collection; collection of peripheral blood mononuclear cells
Active Comparator: Second Intervention (3 weeks)
Once daily 80mg chloroquine or placebo tablet 3 Weeks followed by euglycemic clamp procedure; 24 hour Ambulatory Blood Pressure; Oral Glucose tolerance Test; serum collection; 24 hour urine collection; collection of peripheral blood mononuclear cells
Active Comparator: Third Intervention (3 weeks)
Once daily 80mg tablet for 3 weeks followed by: euglycemic clamp procedure; 24 hour Ambulatory Blood Pressure; Oral Glucose tolerance Test; serum collection; 24 hour urine collection; collection of peripheral blood mononuclear cells
Active Comparator: Fourth Intervention (3 weeks)
Once daily 250mg tablet for 3 weeks followed by: euglycemic clamp procedure; 24 hour Ambulatory Blood Pressure; Oral Glucose tolerance Test; serum collection; 24 hour urine collection; collection of peripheral blood mononuclear cells
Washington University in St. Louis, St Louis
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Washington University School of Medicine
OTHER