Combination Chemotherapy With or Without Gemtuzumab Ozogamicin or Tipifarnib in Treating Patients With Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndromes

PHASE2/PHASE3CompletedINTERVENTIONAL
Enrollment

2,000

Participants

Timeline

Start Date

August 31, 2006

Primary Completion Date

August 31, 2012

Conditions
LeukemiaMyelodysplastic Syndromes
Interventions
BIOLOGICAL

alemtuzumab

DRUG

arsenic trioxide

DRUG

azacitidine

DRUG

busulfan

DRUG

clofarabine

DRUG

cytarabine

DRUG

daunorubicin hydrochloride

DRUG

fludarabine phosphate

DRUG

gemtuzumab ozogamicin

DRUG

melphalan

DRUG

tipifarnib

GENETIC

DNA methylation analysis

GENETIC

cytogenetic analysis

GENETIC

gene expression analysis

GENETIC

mutation analysis

OTHER

diagnostic laboratory biomarker analysis

OTHER

immunologic technique

PROCEDURE

allogeneic hematopoietic stem cell transplantation

PROCEDURE

nonmyeloablative allogeneic hematopoietic stem cell transplantation

Trial Locations (96)

RG24 9NA

Basingstoke and North Hampshire NHS Foundation Trust, Basingstoke

BA1 3NG

Royal United Hospital, Bath

B15 2TH

Queen Elizabeth Hospital at University Hospital of Birmingham NHS Trust, Birmingham

B9 5SS

Birmingham Heartlands Hospital, Birmingham

FY3 8NR

Blackpool Victoria Hospital, Blackpool

BH7 7DW

Royal Bournemouth Hospital, Bournemouth

BD9 6RJ

Bradford Royal Infirmary, Bradford

BN2 5BE

Sussex Cancer Centre at Royal Sussex County Hospital, Brighton

DE13 0RB

Queen's Hospital, Burton-on-Trent

IP33 2QZ

West Suffolk Hospital, Bury St Edmunds

CB2 2QQ

Addenbrooke's Hospital, Cambridge

CT1 3NG

Kent and Canterbury Hospital, Canterbury

SM5 1AA

St. Helier Hospital, Carshalton

GL53 7AN

Gloucestershire Oncology Centre at Cheltenham General Hospital, Cheltenham

CH2 1UL

Countess of Chester Hospital, Chester

S44 5BL

Chesterfield Royal Hospital, Chesterfield

P019 4SE

Saint Richards Hospital, Chichester

CV2 2DX

Walsgrave Hospital, Coventry

Unknown

Mayday University Hospital, Croydon

Wycombe General Hospital, High Wycombe

Royal Alexandra Hospital, Paisley

DE1 2QY

Derbyshire Royal Infirmary, Derby

DN2 5LT

Doncaster Royal Infirmary, Doncaster

DT1 2JY

Dorset County Hospital, Dorchester

DY1 2HQ

Russells Hall Hospital, Dudley

EX2 5DW

Royal Devon and Exeter Hospital, Exeter

ME7 5NY

Medway Maritime Hospital, Gillingham Kent

HG2 7SX

Harrogate District Hospital, Harrogate

HA1 3UJ

Northwick Park Hospital, Harrow

HP2 4AD

Hemel Hempstead General, Hemel Hempstead

HU3 2KZ

Hull Royal Infirmary, Hull

IP4 5PD

Ipswich Hospital, Ipswich

TW7 6AF

West Middlesex University Hospital, Isleworth

NNI6 8UZ

Kettering General Hosptial, Kettering, Northants

DY11 6RJ

Kidderminster Hospital, Kidderminster Worcestershire

KA2 OBE

Crosshouse Hospital, Kilmarnock

LS1 3EX

Leeds General Infirmary, Leeds

LE1 5WW

Leicester Royal Infirmary, Leicester

L7 8XP

Royal Liverpool University Hospital, Liverpool

L9 7AL

Aintree University Hospital, Liverpool

EC1A 7BE

Saint Bartholomew's Hospital, London

NW1 2QG

UCL Cancer Institute, London

SE13 6LH

University Hospital Lewisham, London

SE18 4QH

Queen Elizabeth Hospital - Woolwich, London

SE5 8RX

King's College Hospital, London

SW17 0QT

St. George's Hospital, London

WC1E 6AU

University College Hospital - London, London

ME16 9QQ

Maidstone Hospital, Maidstone

M13 9WL

Manchester Royal Infirmary, Manchester

M20 4BX

Christie Hospital, Manchester

M31 3SL

Trafford General Hospital, Manchester

TD6 9BS

Borders General Hospital, Melrose

CH49 5PE

Arrowe Park Hospital, Metropolitan Borough of Wirral

NR31 6LA

James Paget Hospital, Norfolk

NG5 1PB

Nottingham City Hospital, Nottingham

PL6 8DH

Derriford Hospital, Plymouth

L35 5DR

Whiston Hospital, Prescot Merseyside

RG1 5AN

Berkshire Cancer Centre at Royal Berkshire Hospital, Reading

TN37 7RD

Conquest Hospital, Saint Leonards-on-Sea

M6 8HD

Hope Hospital, Salford

SP2 8BJ

Salisbury District Hospital, Salisbury

S1O 2JF

Royal Hallamshire Hospital, Sheffield

SO16 6YD

Southampton General Hospital, Southampton

PR8 6PN

Southport and Formby District General Hospital, Southport

ST16 3SA

Staffordshire General Hospital, Stafford

SR4 7TP

Sunderland Royal Hospital, Sunderland

SM2 5PT

Royal Marsden - Surrey, Sutton

SN3 6BB

Great Western Hospital, Swindon

TA1 5DA

Taunton and Somerset Hospital, Taunton Somerset

TQ2 7AA

Torbay Hospital, Torquay

TR1 3LJ

Royal Cornwall Hospital, Truro, Cornwall

UB8 3NN

Hillingdon Hospital, Uxbridge

B71 4HJ

Sandwell General Hospital, West Bromwich

WR5 1DD

Worcester Royal Hospital, Worcester

BN11 2DH

Worthing Hospital, Worthing

Y031 8HE

Cancer Care Center, York

AB25 2ZN

Aberdeen Royal Infirmary, Aberdeen

ML6 0JF

Monklands General Hospital, Airdrie

DD1 9SY

Ninewells Hospital, Dundee

EH4 2XU

Edinburgh Cancer Centre at Western General Hospital, Edinburgh

FK1 5QE

Falkirk and District Royal Infirmary, Falkirk

G11 6NT

Western Infirmary, Glasgow

G4 0SF

Royal Infirmary - Castle, Glasgow

G42 9TY

Victoria Infirmary, Glasgow

G51 4TF

Southern General Hospital, Glasgow

1V2 3UJ

Raigmore Hospital, Inverness

KY2 5AH

Victoria Hospital, Kirkcaldy

WF1 4DG

Dorset Cancer Centre, Wakefield

Pinderfields General Hospital, Wakefield

LL57 2PW

Ysbyty Gwynedd, Bangor

CF14 4XW

University Hospital of Wales, Cardiff

LL 18 5UJ

Glan Clwyd Hospital, Rhyl, Denbighshire

SA2 8QA

South West Wales Cancer Institute, Swansea

HR1 2ER

Hereford Hospitals, Hereford

SL2 4HL

Wexham Park Hospital, Slough, Berkshire

KT2 7QB

Kingston Hospital, Surrey

All Listed Sponsors
lead

The University of New South Wales

OTHER

NCT00454480 - Combination Chemotherapy With or Without Gemtuzumab Ozogamicin or Tipifarnib in Treating Patients With Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndromes | Biotech Hunter | Biotech Hunter