Evaluation of Efficacy and Safety of Peramivir in Adults With Acute Serious or Potentially Life-threatening Influenza

PHASE2CompletedINTERVENTIONAL
Enrollment

137

Participants

Timeline

Start Date

July 31, 2007

Primary Completion Date

September 30, 2008

Study Completion Date

August 31, 2009

Conditions
Influenza
Interventions
DRUG

Peramivir 200 mg

Peramivir (200 mg in 100 mL of solution) intravenous infusion (over 15 minutes) and an orally administered oseltamivir placebo suspension (6.25 mL) treatment

DRUG

Peramivir 400 mg

Peramivir (400 mg in 100 mL of solution ) intravenous infusion (over 15 minutes) and an orally administered oseltamivir placebo suspension (6.25 ml)

DRUG

Oseltamivir

Placebo peramivir infusion (over 15 minutes) and a 75-mg dose of oseltamivir suspension (6.25 mL)

Trial Locations (83)

1201

Eksteen, MC, Mbombela

1500

Benmed / Pentagon Hospital, Benoni

1724

Private Practice, Cape Town

1739

DJW Navorsing, Krugersdorp

1818

Dr Bhorat, Soweto

2001

Newgate Centre, Johannesburg

2031

Prince Of Wales Hospital, Randwick

2145

Westmead Hospital, Wentworthville

3050

Royal Melbourne Hospital, Parkville

3110

Tauranga Hospital, Tauranga

4001

Sebastian, P, Durban

4101

Mater Adult Hospital, South Brisbane

4102

Princess Alexandra Hospital, Woolloongabba

4215

Gold Coast Hospital, Southport

4870

Cairns Base Hospital, Cairns

5041

Repatriation General Hospital, Daw Park

6020

Global Clinical Trial Center, Port Elizabeth

6060

Sir Charles Gairdner Hospital, Nedlands

6850

Dr. L.J. van Zyl, Worcester

7460

N1 City Hospital, Cape Town

9301

Genclin Corporation, Bloemfontein

14642

University of Rochester Medical Center, Rochester

19140

Temple University Hospital, Philadelphia

21201

VA Maryland Health Care System, Baltimore

21237

Franklin Square Hospital, Baltimore

24153

Veterans Affairs Medical Center, Salem

29414

Lowcountry Infectious Diseases, P.A., Charleston

30033

Infectious Disease Specialists of Atlanta, P.C., Decatur

30912

Medical College of Georgia, Augusta

31405

St. Joseph's/Candler Health System, Inc., Savannah

32806

Orlando Regional Healthcare, Orlando

33612

James A. Haley Veterans Hospital, Department of Infectious Disease, Tampa

36608

Pulmonary Associates of Mobile, P.C., Mobile

46202

Wishard Hospital/Indiana University, Indianapolis

46280

Infectious Disease of Indiana, PSC, Indianapolis

48085

William Beaumont Hospital Troy, Troy

48201

Wayne State University School of Medicine, Detroit

48202

Henry Ford Health System, Detroit

59701

Mercury Street Medical Group, PLLC, Butte

60611

Northwestern University, Chicago

62701

Springfield Clinic, LLP, Springfield

63110

Washington University School of Medicine, St Louis

71103

Louisiana State University Health Sciences Center-Shreveport, Shreveport

71457

Natchitoches Internal Medicine, Natchitoches

72401

St. Bernards Research Center/Clopton Clinic, Jonesboro

77030

Baylor College of Medicine, Houston

80206

National Jewish Medical and Research Center, Clinical Research Unit, Denver

83404

Idaho Falls Infectious Diseases, PLLC, Idaho Falls

84132

University of Utah Health Sciences Center, Salt Lake City

92868

Pulmonary Consultants & Primary Care Physicians Medical Group, Inc., Orange

University of California Irvine Medical Center, Orange

95124

Good Samaritan Hospital, San Jose

95817

University of California Davis Medical Center, Department of Emergency Medicine, Sacramento

98405

Franciscan Health System, Tacoma

169608

National University Hospital, Singapore

308433

Tan Tock Seng Hospital, Singapore

02215

Beth Israel Deaconess Medical Center, Boston

07601

Hackensack University Medical Center, Department of Infectious Disease, Hackensack

07754

Jersey Shore University Medical Center, Neptune City

87131-0001

University of New Mexico, Albuquerque

14621-3001

Rochester General Hospital/University of Rochester, Rochester

44106-5083

University Hospitals Case Medical Center, Cleveland

54449-5703

Marshfield Clinic, Marshfield

53226-3522

Medical College of Wisconsin, Milwaukee

V1Y 3T1

Kelowna General Hospital, Kelowna

L8N 3Z5

Hamilton Health Sciences-McMaster University Medical Centre, Hamilton

L8N 4A6

St. Joseph's Healthcare Hamilton-L424, Hamilton

K1H 8L6

The Ottawa Hospital - General Campus, Ottawa

M5G 1X5

Mount Sinai Hospital / Toronto Medical Laboratories, Toronto

G7H 5H6

Center de Sante et des Services Sociaux de Chicoutimi, Chicoutimi

H1T 2M4

Maisonneuve-Rosemont Hospital, Montreal

G1V 4G2

Centre Hospitalier Universitaire de Quebec-Pavillon CHUL, Québec

G5L 5T1

Centre de sante et de services sociaux Rimouski-Neigette (CSSSRN), Rimouski

S7N 0W8

Division of Infectious Diseases, Saskatoon

Unknown

Princess Margaret Hospital, Hong Kong

Queen Mary Hospital, Hong Kong

United Christian Hospital, Hong Kong

The Prince of Wales Hospital, Shatin - New Territories

Christchurch Hospital, Christchurch

Waikato Hospital, Hamilton

0001

Medforum Hospital, Pretoria

0084

Eugene Marais Hospital, Pretoria

0186

Global Clinical Trials (GCT), Pretoria

Sponsors
All Listed Sponsors
lead

BioCryst Pharmaceuticals

INDUSTRY