Efficacy and Safety Study of 3 Thalidomide Doses for the Treatment of Relapsed Refractory Multiple Myeloma

PHASE3CompletedINTERVENTIONAL
Enrollment

499

Participants

Timeline

Start Date

February 1, 2006

Primary Completion Date

December 1, 2008

Study Completion Date

January 1, 2009

Conditions
Multiple Myeloma
Interventions
DRUG

Thalidomide

Oral thalidomide (100mg or 200mg or 400 mg/day) administered to the patient once daily until progression of the disease and for a maximum of 336 + 36 days (12 cycles of 28 +/- 3 days).

DRUG

Dexamethasone

High dose oral dexamethasone will be administered at a dose of 40mg/day on days 1-4, 9-12 and 17-20 of each 28-day cycle for cycles 1-4. Beginning with cycle 5, the oral dexamethasone dosing schedule will be reduced to 40mg/day on days 1-4 of each 28-day cycle. Dexamethasone will be administered until progression of the disease and for a maximum of 336 +/- 36 days (12 cycles of 28 +/- 3 days).

Trial Locations (86)

1100

Doctors Clinic - National Kidney & Transplant Institute, Quezon City

1102

St. Luke's Medical Center, Quezon City

1108

University of Sto Tomas Hospital, Manila

1200

Doctors Clinic Makati Medical Center, Makati City

1431

"University of Multiprofiled Hospital for Active Treatment Alexandrovska - Sofia", Sofia

1606

Military Medical Academy/Dept Haematology and Oncology, Sofia

1756

National Center of Haematology & Transfusiology, Sofia

2013

Chris Hani Baragwanath Hospital, Clinical Haematology Unit, Johannesburg

2193

Johannesburg Hospital, Department of Medical Oncology, Parktown

2196

Medical Oncology Centre of Rosebank, Johannesburg

2600

Department of Internal Medicine - Baguio General Hospital & Medical Center, Baguio City

4002

Clinic of Haematology, University Multiprofiled Hospital for Active Treatment, Plovdiv

5700

Pandy Kalman Megyei Korhaz, Megyei Onkologiai Centrum, Gyula

5800

"Clinic of Haematology, University Multiprofiled Hospital for Active Treatment G. Stranski", Pleven

6000

Chong Hua Hospital, Cebu City

6720

Szent-Gyorgyi Albert University II Clinic of Internal Medicine, Szeged

7505

Tygerberg Hospital, University of Stellenbosch, Department of Haematology, Cape Town

9010

"Clinic of Haematology, Multiprofiled Hospital for Active Treatment Sveta Marina", Varna

9301

University of Free State, Faculty of Health Science, Dept of Hematology & Cell Biology, Bloemfontein

10000

KBC Zagreb - Klinika za Unutarnje Bolesti, Zagreb

"Klinicka Bolnica Dubrava Klinika za Unutarnje Bolesti", Zagreb

"Klinicka Bolnica Sestre milosrdnice Klinika za Unutarnje Bolesti", Zagreb

Klinicka Bolnica MERKUR - Klinika za Unutarnje Bolesti, Zagreb

11000

Institute of Hematology, Clinical Centre of Serbia, Belgrade

13125

Charite, Universitatsmedizin Berlin, Campus Robert-Rossle Klinik, Berlin

18000

Clinic for Hematology, Clinical Centre Nis, Niš

21000

Klinika Bolnica SPLIT - Klinika za Unutarnje Bolesti, Split

Clinic for Hematology, Clinical Centre Novi Sad, Novisad

22763

Abt. Haematologie - Onkologie/ Allg. Krankenhaus, Hamburg

24116

Universitat Schleswig Holstein II Med. Klinik, Kiel

31059

Hematologie - CHU Purpan Place du Dr. Baylac, Toulouse

40138

Instituto di Ematologia e Oncologia Medica, Bologna

40225

Hematology, Oncology & Clinical Immunology/Heinrich-Heine-University, Düsseldorf

48149

Innere Medizin University Hospital, Münster

50924

Universitaetsklinik - Klinik fur innere Medizin, Cologne

51000

Klinicki Bolnicki Centar Rijeka Interna Klinika, Rijeka

53105

Med. Klinik I/University Bonn, Bonn

54511

CHU de Nancy - Hopital Brabois, Nancy

59037

CHRU de Lille - Hopital Claude Huriez, Lille

69120

Medizinische Klinik Abteilung Innere V/Universitatsklinikum, Heidelberg

70376

Robert-Bosch-Krankenhaus GmbH, Stuttgart, Stuttgart

73601

Onkologicke Centrum J.G. Mendela, Novi Jicin

83310

Department of Internal Medicine, National Cancer Institute, Bratilslava

85107

Hematology Department University Hospital, Bratilslava

89081

Universitaetsklinik - Abteilung Innere Medizin III, Ulm

97070

Med. Klinik II/Klinikum of the Julius-Maximilians-University, Würzburg

310126

Dipartimento Medicina ed Oncologia Sperimentale - Divisione Universitaria di Ematologia Azienda Ospedaliera S. Giovanni Battista, Torino

351135

National Medical Centre Dpt Haematology, Budapest

400012

Department of Medical Oncology/Tata Memorial Hospital, Mumbai

400016

Department of Medical Oncology, S.L. Raheja Hospital, Mumbai

400026

Department of Medical Oncology, Jaslok Hospital and Research Centre, Mumbai

411004

Department of Medical Oncology, Deenanath Mangeshkar Hospital, Pune

500082

Nizam's Institute of Medical Sciences, Department of Medical Oncology, Hyderabaad

700054

Orchid Nursing Home, Kolkata

20 625 00

Interni Hemato-Onkologicka Klinika, Brno

48 500 05

Hematologicka Klinika, Fakultni Nemocnice Hradec Kralove, Hradec Králové

6 775 20

Interni Klinika, Oddeleni Hematoonkologie, Olomouc

2128 08

Interni Klinika, Oddeleni Hematoonkologie, Prague

50 100 34

Hematologicka Klinika, Fakultni Nemocnice Kralovske Vinohrady Srobarova, Prague

01307

Medizinische Klinik und Poliklinik I/Carl-Gustav-Carus University, Dresden

D-20099

Allgemeinse Krankenhaus St. Georg Hamatologische Abteilung, Hamburg

D-81377

Medizinische Klinik und Poliklinik III/Klinikum der Universitaet Muenchen, München

D-06120

Abteilung Haematologie - Univeresitaetsklinikum, Saale

H-9024

Petz Aladar Megyei Oktato Korhaz, II. Belgyogyaszat, Győr

682 026

Department of Medical Oncology, Amrita Institute of Medical Sciences, Kerala

141 001

Department of Medical Oncology, Dayanand Medical College DMCH, Ludhiana

695 011

Department of Medical Oncology/Regional Cancer Centre, Trivandrum

15-276

SPSK, Klinika Hematologii Akademii Medycznej, Bialystok

80-952

Klinika Hematologii Akademii Medycznej w Gdanskuul, Gdansk

40-027

Katedra i Klinika Hematologii i Transplantacji Szpiku - Slaska Akademia Medyczna, Katowice

25-734

Swietokrzyskie Centrum Onkologii SPZOZ Poradnia Hematologii, Kielce

93-510

Klinika Hematologii Uniwersytetu Medycznego, Lodz

00-909

Klinika Chorob Wewnetrznych i Hemagologii, Warsaw

02-097

Katedra i Klinika Hematologii, Onkologii I Chorob Wewnetrznych, Warsaw

02-776

Instytut Hematologii i Transfuzjologii - Klinika Hematologiczna, Warsaw

02-781

Centrum Onkologii-Instytut im. Marii Sklodowskiej-Curie, Warsaw

50-367

Klinika Hematologii Nowotworow Krwi i Transplantacji - Szpiku Akademii Medycznej, Wroclaw

3000-075

Hospital da Universidade de Coimbra - Servico de Hematologia Clinica, Coimbra

1099-023

Instituto Portugues de Oncologia, Lisbon

4099-001

Hospital Geral de Santo Antonio - Servico de Hematologia Clinica, Porto

04066

Hematology Department, University Hospital PJS, Košice

Unknown

Department of Haematology, UCT Medical School, Cape Town

B95 SS

Oncology Research Unit Heartlands Hospital, Birmingham

SE1 9RT

Clinical Haematology, Guy's Hospital, London

SE5 9RS

Haematology Department - King's College Hospital, London

SM2 5PT

Department of Haematology-Oncology, The Royal Marsden NHS Foundation Trust, Surrey

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Celgene

INDUSTRY

NCT00452569 - Efficacy and Safety Study of 3 Thalidomide Doses for the Treatment of Relapsed Refractory Multiple Myeloma | Biotech Hunter | Biotech Hunter