64
Participants
Start Date
February 23, 2007
Primary Completion Date
April 27, 2017
Study Completion Date
June 8, 2017
Sargramostim (GM-CSF, Leukine)
A recombinant human granulocyte-macrophage colony stimulating factor (GM-CSF) produced by recombinant deoxyribonucleic acid (DNA) technology in yeast Saccharomyces cerevisiae). Sargramostim is a 127 amino acid glycoprotein, altered from the native, natural human GM-CSF molecule; the position 23 arginine has been replaced with a leucine to facilitate the expression of the protein in yeast.
Flutamide (Eulexin)
Orally administered, nonsteroidal, competitive antagonist of testosterone and other androgens at androgenic receptors and may alter the nuclear translocation of the androgen/receptor complex.
PROSTVAC-F/ TRICOM
A recombinant fowlpox virus vector vaccine containing the genes for human PSA and three costimulatory molecules.
PROSTVAC-V/TRICOM
A recombinant vaccinia virus vector vaccine containing the genes for human prostatic specific antigen (PSA) and three co-stimulatory molecules.
Fox Chase Cancer Center, Philadelphia
National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda
Cancer Institute of New Jersey, New Brunswick
National Cancer Institute (NCI)
NIH