1,103
Participants
Start Date
October 31, 2007
Primary Completion Date
December 31, 2017
Study Completion Date
December 31, 2017
bevacizumab
7.5mg/kg IV Day 1 of each 21 cycle of chemotherapy (6 cycles) plus day 1 of each maintenance dose every 21 days for 6 doses.
capecitabine
dose banded as based on patient BSA. Oral dose given twice a day during each 21 day cycle of chemotherapy (6 cycles in total)
cisplatin
60mg/m2 IV day one of each 21 day cycle of chemotherapy (6 cycles in total)
Epirubicin
50mg/m2 IV day one of each 21 day cycle of chemotherapy (6 cycles in total)
adjuvant therapy
3 cycles of ECX chemotherapy post operatively
conventional surgery
Surgery undertaken after 3 cycles of pre-operative chemotherapy. Followed by 3 cycles of chemotherapy.
neoadjuvant therapy
3 cycles of pre-operative ECX chemotherapy.
Lapatinib
1250mg/day Day 1-21 of each cycle of chemotherapy (6 cycles) plus day 1-21 of each maintenance course every 21 days for 6 doses.
RECRUITING
Royal Bournemouth Hospital, Bournemouth
ACTIVE_NOT_RECRUITING
Bradford Royal Infirmary, Bradford
RECRUITING
Bristol Haematology and Oncology Centre, Bristol
ACTIVE_NOT_RECRUITING
Addenbrooke's Hospital, Cambridge
ACTIVE_NOT_RECRUITING
Cumberland Infirmary, Carlisle
RECRUITING
Doncaster Royal Infirmary, Doncaster
RECRUITING
St. Luke's Cancer Centre at Royal Surrey County Hospital, Guildford
RECRUITING
Huddersfield Royal Infirmary, Huddersfield, West Yorks
RECRUITING
Leeds Cancer Centre at St. James's University Hospital, Leeds
ACTIVE_NOT_RECRUITING
Lincoln County Hospital, Lincoln
RECRUITING
Aintree University Hospital, Liverpool
RECRUITING
Saint Bartholomew's Hospital, London
ACTIVE_NOT_RECRUITING
St. George's Hospital, London
ACTIVE_NOT_RECRUITING
St. Mary's Hospital, London
RECRUITING
Mid Kent Oncology Centre at Maidstone Hospital, Maidstone
RECRUITING
Christie Hospital, Manchester
RECRUITING
Clatterbridge Centre for Oncology, Merseyside
RECRUITING
Northern Centre for Cancer Treatment at Newcastle General Hospital, Newcastle upon Tyne
ACTIVE_NOT_RECRUITING
Derriford Hospital, Plymouth
ACTIVE_NOT_RECRUITING
Dorset Cancer Centre, Poole Dorset
RECRUITING
Berkshire Cancer Centre at Royal Berkshire Hospital, Reading
ACTIVE_NOT_RECRUITING
Rochdale Infirmary, Rochdale
RECRUITING
Salisbury District Hospital, Salisbury
RECRUITING
Wexham Park Hospital, Slough, Berkshire
RECRUITING
Southampton General Hospital, Southampton
RECRUITING
Royal Marsden - Surrey, Sutton
RECRUITING
Aberdeen Royal Infirmary, Aberdeen
RECRUITING
Velindre Cancer Center at Velindre Hospital, Cardiff
RECRUITING
Basingstoke and North Hampshire Hospital, Basingstoke
RECRUITING
Birmingham Heartlands Hospital, Birmingham
RECRUITING
Castle Hill Hospital, Cottingham
RECRUITING
University Hospitals Coventry and Warwickshire, Coventry
RECRUITING
Beatson West of Scotland Cancer Centre, Glasgow
RECRUITING
St James Hospital, Leeds
RECRUITING
Leicester Royal Infirmary, Leicester
RECRUITING
Norfolk and Norwich University Hospital, Norwich
RECRUITING
Churchill Hospital, Oxford
RECRUITING
Queens Hospital, Romford
RECRUITING
Weston Park, Sheffield
RECRUITING
Great Western Hospital, Swindon
RECRUITING
Musgrove Park Hospital, Taunton
Collaborators (2)
Cancer Research UK
OTHER
Roche Pharma AG
INDUSTRY
GlaxoSmithKline
INDUSTRY
Professor David Cunningham
OTHER_GOV