NCT00445744View on ClinicalTrials.gov

Cyclophosphamide and Busulfan Followed by Donor Stem Cell Transplant in Treating Patients With Myelofibrosis, Acute Myeloid Leukemia, or Myelodysplastic Syndrome

NACompletedINTERVENTIONAL
Enrollment

52

Participants

Timeline

Start Date

December 31, 2006

Primary Completion Date

June 30, 2011

Study Completion Date

June 30, 2013

Conditions
Adult Acute Myeloid Leukemia in RemissionAdult Acute Myeloid Leukemia With 11q23 (MLL) AbnormalitiesAdult Acute Myeloid Leukemia With Del(5q)Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)Childhood Acute Myeloid Leukemia in RemissionChildhood Myelodysplastic Syndromesde Novo Myelodysplastic SyndromesEssential ThrombocythemiaMyelodysplastic Syndrome With Isolated Del(5q)Polycythemia VeraPreviously Treated Myelodysplastic SyndromesPrimary MyelofibrosisRecurrent Adult Acute Myeloid LeukemiaRecurrent Childhood Acute Myeloid LeukemiaSecondary Acute Myeloid LeukemiaSecondary Myelodysplastic SyndromesSecondary MyelofibrosisUntreated Adult Acute Myeloid LeukemiaUntreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies
Interventions
DRUG

cyclophosphamide

Given IV

DRUG

busulfan

Given IV

DRUG

tacrolimus

Given IV or PO

DRUG

methotrexate

Given IV

GENETIC

cytogenetic analysis

Correlative studies

OTHER

flow cytometry

Correlative studies

OTHER

pharmacological study

Correlative studies

OTHER

pharmacogenomic studies

Correlative studies

PROCEDURE

peripheral blood stem cell transplantation

Undergo PBPC transplantation

PROCEDURE

allogeneic hematopoietic stem cell transplantation

Undergo allogeneic transplantation

Trial Locations (1)

98109

Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium, Seattle

All Listed Sponsors
collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

collaborator

National Cancer Institute (NCI)

NIH

lead

Fred Hutchinson Cancer Center

OTHER

NCT00445744 - Cyclophosphamide and Busulfan Followed by Donor Stem Cell Transplant in Treating Patients With Myelofibrosis, Acute Myeloid Leukemia, or Myelodysplastic Syndrome | Biotech Hunter | Biotech Hunter