889
Participants
Start Date
May 31, 2007
Primary Completion Date
December 31, 2009
Study Completion Date
March 31, 2010
Tenofovir gel
Participants will be provided with a supply of single-use, pre-filled applicators according to their randomisation. While in the study, participants will be asked to apply a first dose of the assigned study product, 1% tenofovir gel, within 12 hours prior to coitus and insert a second dose as soon as possible within 12 hours after coitus. They will be advised to use only two doses of gel in a 24-hour period.
Placebo (Universal HEC placebo)
Participants will be provided with a supply of single-use, pre-filled applicators according to their randomisation. While in the study, participants will be asked to apply a first dose of the assigned study product, placebo gel, within 12 hours prior to coitus and insert a second dose as soon as possible within 12 hours after coitus. They will be advised to use only two doses of gel in a 24-hour period.
CAPRISA eThekwini Clinical Research Site, Durban
CAPRISA, Vulindlela Clinical Research Site, Pietermaritzburg
FHI 360
OTHER
United States Agency for International Development (USAID)
FED
CONRAD
OTHER
Centre for the AIDS Programme of Research in South Africa
NETWORK