Synchronization of Follicle Wave Emergence and Ovarian Stimulation

PHASE4CompletedINTERVENTIONAL
Enrollment

80

Participants

Timeline

Start Date

February 28, 2007

Primary Completion Date

May 31, 2010

Study Completion Date

May 31, 2010

Conditions
Infertility
Interventions
DRUG

Gonal F

"* 450 IU Gonal-f (Serono Canada) subcutaneously daily (225 IU BID; injections to be given after bloodwork).~* Dosing to begin on day 1 or day 4 (day 1=first day of menses), continuing until administration of human Chorionic Gonadotropin (hCG; see below).~* Gonal-f dose may be further reduced, at the discretion of the study physician, to minimize the risk of OHSS."

DRUG

Luveris

"* 0.250 mg Cetrotide (Serono Canada) and 75 IU Luveris (Serono Canada) subcutaneously daily when one or more of the following conditions are met:~ * leading follicle is \> 13 mm in diameter~ * if 6 or more follicles develop to \> 10 mm and E2 \> 1000 pmol/L~* Dosing to continue until administration of hCG (see below)."

DRUG

Cetrotide

"* 0.250 mg Cetrotide (Serono Canada) and 75 IU Luveris (Serono Canada) subcutaneously daily when one or more of the following conditions are met:~ * leading follicle is \> 13 mm in diameter~ * if 6 or more follicles develop to \> 10 mm and E2 \> 1000 pmol/L~* Dosing to continue until administration of hCG (see below)."

DRUG

hCG

"\- 10,000 IU hCG (Pharmaceutical Partners of Canada Inc.) subcutaneously when:~o \> 3 follicles are \> 17 mm in diameter"

Trial Locations (2)

V5Z 3X7

Genesis Fertility Centre, Vancouver

S7N0W8

Department of Obstetrics, Gynecology and Reproductive Sciences, University of Saskatchewan, Saskatoon

All Listed Sponsors
collaborator

Royal University Hospital Foundation

OTHER

lead

University of Saskatchewan

OTHER

NCT00439829 - Synchronization of Follicle Wave Emergence and Ovarian Stimulation | Biotech Hunter | Biotech Hunter