Etoposide and Cisplatin or Carboplatin as First-Line Chemotherapy With or Without Pravastatin in Treating Patients With Small Cell Lung Cancer

PHASE3CompletedINTERVENTIONAL
Enrollment

846

Participants

Timeline

Start Date

January 31, 2007

Primary Completion Date

January 31, 2012

Study Completion Date

November 30, 2013

Conditions
Lung Cancer
Interventions
DRUG

carboplatin

Should be given according to local practice but suggested doses and schedules are provided in the protocol.

DRUG

cisplatin

Should be given according to local practice but suggested doses and schedules are provided in the protocol.

DRUG

etoposide phosphate

Day 1: given by IV, days 2 and 3 given by IV or oral. Dose should be given according to local practice but suggested doses and schedules are provided in the protocol.

DRUG

pravastatin sodium

40mg daily oral tablet taken for a maximum of 2 years

Trial Locations (86)

TN24 0LZ

William Harvey Hospital, Ashford-Kent

HP21 8AL

Stoke Mandeville Hospital, Aylesbury-Buckinghamshire

EX31 4JB

North Devon District Hospital, Barnstaple

BA1 3NG

Royal United Hospital, Bath

B18 7QH

City Hospital - Birmingham, Birmingham

B71 4HJ

Sandwell General Hospital, Birmingham

B75 7RR

Good Hope Hospital, Birmingham

B9 5SS

Birmingham Heartlands Hospital, Birmingham

BH7 7DW

Royal Bournemouth Hospital, Bournemouth

BD9 6RJ

Bradford Royal Infirmary, Bradford

BN2 5BE

Sussex Cancer Centre at Royal Sussex County Hospital, Brighton

DE13 0RB

Queen's Hospital, Burton-on-Trent

CB2 2QQ

Addenbrooke's Hospital, Cambridge

CT1 3NG

Kent and Canterbury Hospital, Canterbury

CM1 7ET

Broomfield Hospital, Chelmsford

GL53 7AN

Gloucestershire Oncology Centre at Cheltenham General Hospital, Cheltenham

C03 3NB

Essex County Hospital, Colchester

PO6 3LY

Queen Alexandra Hospital, Cosham

DA2 8DA

Darent Valley Hospital, Dartford Kent

DE22 3NE

Royal Derby Hospital, Derby

DT1 2JY

Dorset County Hospital, Dorchester

DH1 5TW

University Hospital of North Durham, Durham

CM20 1QX

Princess Alexandra Hospital, Essex

EX2 5DW

Royal Devon and Exeter Hospital, Exeter

GL1 3NN

Gloucestershire Royal Hospital, Gloucester

DN33 2BA

Diana Princess of Wales Hospital, Grimsby

GU2 7XX

St. Luke's Cancer Centre at Royal Surrey County Hospital, Guildford

HG2 7SX

Harrogate District Hospital, Harrogate

HR1 2ER

Hereford Hospitals, Hereford

Unknown

Wycombe General Hospital, High Wycombe

Nevill Hall Hospital, Gwent

HD3 3EA

Huddersfield Royal Infirmary, Huddersfield, West Yorks

HU16 5JQ

Castle Hill Hospital, Hull

IP4 5PD

Ipswich Hospital, Ipswich

BD20 6TD

Airedale General Hospital, Keighley

PE30 4ET

Queen Elizabeth Hospital, Kings Lynn

LS16 6QB

Cancer Research UK Clinical Centre at St. James's University Hospital, Leeds

LE1 5WW

Leicester Royal Infirmary, Leicester

NW1 2BU

University College Hospital, London

SE1 9RT

Guy's Hospital, London

SE18 4QH

Queen Elizabeth Hospital - Woolwich, London

SW17 0QT

St. George's Hospital, London

W6 8RF

Charing Cross Hospital, London

LU4 0DZ

Luton and Dunstable Hospital, Luton

ME16 9QQ

Maidstone Hospital, Maidstone

M20 4BX

Christie Hospital, Manchester

M23 9LJ

Wythenshawe Hospital, Manchester

CT9 4AN

Queen Elizabeth The Queen Mother Hospital, Margate

TS4 3BW

James Cook University Hospital, Middlesbrough

MK6 5LD

Milton Keynes General Hospital, Milton Keynes

NE7 7DN

Freeman Hospital, Newcastle upon Tyne

PO30 5TG

St. Mary's Hospital, Newport

DL6 1JG

Friarage Hospital, North Yorks

HA6 2RN

Mount Vernon Cancer Centre at Mount Vernon Hospital, Northwood

NG5 1PB

Northampton General Hospital, Nottingham

Nottingham City Hospital, Nottingham

NG17 4JL

King's Mills Hospital, Nottinghamshire

BR6 8ND

Princess Royal University Hospital, Orpington, Kent

PE3 6DA

Peterborough Hospitals Trust, Peterborough

PL6 8DH

Derriford Hospital, Plymouth

BH15 2JB

Dorset Cancer Centre, Poole Dorset

RG1 5AN

Berkshire Cancer Centre at Royal Berkshire Hospital, Reading

SP2 8BJ

Salisbury District Hospital, Salisbury

YO12 6QL

Scarborough General Hospital, Scarborough

DN15 7BH

Scunthorpe General Hospital, Scunthorpe

SY3 8XQ

Royal Shrewsbury Hospital, Shrewsbury

SL2 4HL

Wexham Park Hospital, Slough, Berkshire

NE34 0PL

South Tyneside District Hospital, South Shields

SO16 6YD

Southampton General Hospital, Southampton

SG1 4AB

Lister Hospital, Stevenage

TQ2 7AA

Torbay Hospital, Torquay

WS2 9PS

Walsall Manor Hospital, Walsall

BS23 4TQ

Weston General Hospital, Weston-super-Mare

WV10 0QP

New Cross Hospital, Wolverhampton

WR5 1AN

Worcestershire Royal Hospital, Worcester

BN11 2DH

Worthing Hospital, Worthing

BA21 4AT

Yeovil District Hospital, Yeovil

Y031 8HE

Cancer Care Centre at York Hospital, York

AB25 2ZN

Aberdeen Royal Infirmary, Aberdeen

FK1 5QE

Falkirk and District Royal Infirmary, Falkirk

CF14 2TL

Velindre Cancer Center at Velindre Hospital, Cardiff

CF64 2XX

Llandough Hospital, Cardiff

SA61 2PZ

Withybush General Hospital, Haverfordwest

NP9 2UB

Royal Gwent Hospital, Newport Gwent

LL 18 5UJ

Glan Clwyd Hospital, Rhyl, Denbighshire

SA2 8QA

Singleton Hospital, Swansea

All Listed Sponsors
lead

University College, London

OTHER

NCT00433498 - Etoposide and Cisplatin or Carboplatin as First-Line Chemotherapy With or Without Pravastatin in Treating Patients With Small Cell Lung Cancer | Biotech Hunter | Biotech Hunter