Effect of 2 Doses of EPA on Apoptosis and Cell Proliferation on Colon Mucosa

Either 2 x 500mg EPA capsules in the morning and evening (2g per day EPA) or 1 x 500mg EPA and 1 x placebo in the morning and evening (1g per day EPA)

At baseline, month 3 and month 6.

9 biopsies taken for measurement of apoptosis (3 biopsies), cell proliferation (3 biopsies) and fatty acid levels (3 biopsies) at baseline, month 3 and month 6.

Full blood count at baseline, month 3 and month 6.

Urea and electrolytes, liver function tests, clotting profile and CRP at baseline, month 3 and month 6.

Including cardio-respiratory and abdominal examination at baseline, month 3 and month 6.

Height, weight, heart rate, blood pressure and temperature at baseline, month 3 and month 6.

For subjects of child-bearing potential, urine pregnancy test at baseline, month 3 and month 6.

Subjects are requested to complete when study medication is taken and in any new or unusual symptoms are experienced on a daily basis for 6 months.