NCT00431691View on ClinicalTrials.gov

Effect of Antioxidants on Ocular Blood Flow, Endothelial Function, and Cytokine Levels in LPS Induced Inflammatory Model in Humans.

PHASE4CompletedINTERVENTIONAL
Enrollment

22

Participants

Timeline

Start Date

September 30, 2006

Primary Completion Date

December 31, 2007

Study Completion Date

December 31, 2007

Conditions
RetinaRegional Blood FlowEndotoxin, Escherichia Coli
Interventions
DRUG

vitamin and mineral supplement

"dose: 4 tablets daily for two weeks~vitamin A 7160 IU, vitamin C 113mg, vitamin E 100IU, zinc 17.4mg, copper 0.4mg"

DRUG

Escherichia coli Endotoxin (LPS)

dose: 2 ng/kg (corresponding to 20 IU/kg), intravenous bolus over 5 minutes on both study days

DRUG

100% O2

breathing for 30 minutes, 2 breathing periods on both study days

DRUG

nitroglycerin

dose: 0,8 mg sublingual, applied during FMD measurements on both study days

Trial Locations (1)

1090

Department of Clinical Pharmacology, Medical University of Vienna, Vienna

All Listed Sponsors
lead

Medical University of Vienna

OTHER

NCT00431691 - Effect of Antioxidants on Ocular Blood Flow, Endothelial Function, and Cytokine Levels in LPS Induced Inflammatory Model in Humans. | Biotech Hunter | Biotech Hunter