A Two-Step Approach to Bone Marrow Transplant Using Cells From A Partially-Matched Relative

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

27

Participants

Timeline

Start Date

January 31, 2006

Primary Completion Date

August 31, 2009

Study Completion Date

June 30, 2010

Conditions
Hematologic Malignancies
Interventions
RADIATION

Total Body Irradiation (TBI)

TBI twice daily days 6-9 prior to transplant (HSCT)

BIOLOGICAL

Donor Lymphocyte Infusion (DLI)

DLI given 6 days prior to transplant (HSCT).

DRUG

Cyclophosphamide (CY)

Cyclophosphamide given once daily at 60 mg/kg on days 2 and 3 prior to transplant (HSCT).

DRUG

Tacrolimus

Tacrolimus given one day prior to transplant (HSCT).

DRUG

Mycophenolate Mofetil (MMF)

MMF given one day prior to transplant (HSCT).

BIOLOGICAL

Hematopoietic Stem Cell Transplant (HSCT)

CD34+ selected Hematopoietic Stem Cell Transplant (HSCT) is performed. This is the day of transplantation.

Trial Locations (1)

19107

Thomas Jefferson University, Philadelphia

All Listed Sponsors
lead

Sidney Kimmel Cancer Center at Thomas Jefferson University

OTHER

NCT00429143 - A Two-Step Approach to Bone Marrow Transplant Using Cells From A Partially-Matched Relative | Biotech Hunter | Biotech Hunter