Study of Daptomycin in Subjects Undergoing Surgery for Osteomyelitis Associated With an Infected Prosthetic Caused by Staphylococci

PHASE2CompletedINTERVENTIONAL
Enrollment

75

Participants

Timeline

Start Date

June 26, 2007

Primary Completion Date

March 26, 2010

Study Completion Date

June 23, 2010

Conditions
Osteomyelitis
Interventions
DRUG

daptomycin

6 mg/kg

DRUG

daptomycin

8 mg/kg

DRUG

vancomycin

1 gram

DRUG

teicoplanin

6 mg/kg; used only at UK sites

DRUG

nafcillin

1-2 gram

DRUG

oxacillin

1-2 gram

DRUG

flucloxacillin

1-2 mg

Trial Locations (26)

18103

Lehigh Valley Hospital Trauma and Critical Care Research, Allentown

19107

Rothman Institute, Philadelphia

20016

Kane and Davis Associates, Washington D.C.

27157

Wake Forest University Health Sciences, Winston-Salem

33606

Infectious Disease Association of Tampa Bay, Tampa

44195

Cleveland Clinic, Cleveland

44304

Summa Health Systems, Akron

45801

Regional Infectious Diseases-Infusion Center, Lima

54601

Gundersen Clinic, LTD, La Crosse

55905

Mayo Clinic, Rochester

60612

Rush St. Luke's Medical Center, Chicago

62794

Southern Illinois University School of Medicine, Springfield

80133

South Denver Infectious Disease Associates, PC, Englewood

83404

Idaho Falls Infectious Diseases, PLLC, Idaho Falls

89502

Sierra Infectious Disease, Reno

117292

"National Healthcare Institution of Moscow City Clinical Hospital #64", Moscow

195067

"National Educational Institution of Higher Professional Education Saint Petersburg State Medical Academy n.a. Mechnikov of Roszdrav", Saint Petersburg

197046

Russian Research Institute of Traumatology and Orthopedy, Saint Petersburg

443095

"National Healthcare Institution Samara Regional Clinical Hospital n.a. Kalinin", Samara

630091

"Federal Healthcare Institute Novosibirsk Scientific Research Institute of Traumatology and Orthopedy Rosmeditechnology", Novosibirsk

640014

"Federal National Institution of Science Russian Ilizarov Scientific Center Restorative Traumatology and Orthopedics of Rosmedtechnology", Kurgan

72205-7199

UAMS College of Medicine, Little Rock

03756

Dartmouth-Hitchcock Medical center, Lebanon

OX37LD

Nuffield Orthopaedics Centre, Bone Infection Unit, Headington, Oxford

EH164SA

The Royal Infirmary of Edinburgh at Little France, Edinburgh

G120YN

Brownlee Centre - Gartnavel General Hospital, Glasgow

All Listed Sponsors
lead

Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

INDUSTRY

NCT00428844 - Study of Daptomycin in Subjects Undergoing Surgery for Osteomyelitis Associated With an Infected Prosthetic Caused by Staphylococci | Biotech Hunter | Biotech Hunter