Sunitinib and Erlotinib in Treating Patients With Unresectable or Metastatic Kidney Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

August 31, 2006

Primary Completion Date

August 31, 2010

Study Completion Date

March 31, 2014

Conditions
Kidney Cancer
Interventions
DRUG

erlotinib hydrochloride

"Dose Level 0 = 50 mg/day, continuous daily; 0.5= 75 mg/day, continuous daily;~1. 100 mg/day, continuous daily; 1.5= 125 mg/day, continuous daily;~2. 150 mg/day, continuous daily"

DRUG

sunitinib malate

Will be administered at 50 mg daily, 4 weeks on, 2 weeks off

PROCEDURE

biopsy

Paraffin block (or unstained slides) of the primary tumor and/or metastatic lesions (as available) and a plasma sample for future correlative studies will be collected. A paraffin block (or at least 10 unstained slides, each of 10 micromillimeter thickness) from the original paraffin-embedded biopsy material taken at the diagnosis will be stored at 4 degrees Celsius.

Trial Locations (4)

90033

University of Southern California, Los Angeles

97301

Salem Hospital, Salem

97213-2967

Providence Cancer Center at Providence Portland Medical Center, Portland

97239-3098

OHSU Knight Cancer Institute, Portland

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

OHSU Knight Cancer Institute

OTHER

NCT00425386 - Sunitinib and Erlotinib in Treating Patients With Unresectable or Metastatic Kidney Cancer | Biotech Hunter | Biotech Hunter