228
Participants
Start Date
February 28, 2007
Primary Completion Date
April 30, 2009
Study Completion Date
April 30, 2009
ZT-1
Patients in the ZT-1 treatment group will receive ZT 1-1 mg capsules administered p.o. daily during the first month of treatment, followed by ZT-1 implants (9 mg) administered s.c. during the second month of treatment, followed by ZT-1 implants (12 mg) administered s.c. every 4 weeks during months 3 to 6 of treatment. Patients in the ZT-1 treatment group will receive dummy donepezil capsules during months 2 to 6 of the treatment period.
Donepezil
Patients in the donepezil treatment group will receive donepezil 5 mg capsules administered p.o. during the first month of treatment, followed by donepezil 10 mg/day during months 2 to 6 of the treatment period. Patients in the donepezil treatment group will also receive s.c. injections of dummy ZT 1 implants every 4 weeks during months 2 to 6 of the treatment period.
Hornsby-Kuring-gai Health Service, Hornsby
Southern Neurology, Kogarah
Central Coast Neuroscience Research, East Gosford
Austin Health Repatriation Hospital, West Heidelberg
St George's Hospital, Kew
The Prince Charles Hospital, Chermside
Royal Adelaide Hospital, Adelaide
The Queen Elizabeth Hospital, Woodville
Hollywood Specialist Centre, Nedlands (Perth)
Calgary West Medical Centre, Calgary
Castledowns Medicentre, Edmonton
Saibal Nandy Professional Corporation, Medicine Hat
Parkwood Hospital, London
Toronto Memory Program, Toronto
Gerontion Research Inc., Toronto
Neuro Rive-Sud, Montreal
Jewish General Hospital, Montreal
The Medical Arts Health Research Group, Kelowna
Douglas Hospital Research Center, Montreal
The Medical Arts Health Research Group, Penticton
OPMHS, Crowborough
Camden and Islington Mental Health Trust, London
Glasgow Memory Clinic, Glasgow
Llandough Hospital, Penarth
Royal Blackburn Hospital, Blackburn
North Manchester General Hospital, Manchester
New Castle General Hospital, Newcastle upon Tyne
MARC - Moorgreen Hospital, Southampton
Lead Sponsor
Debiopharm International SA
INDUSTRY