A Study of Retreatment With MabThera (Rituximab) in Combination With Methotrexate in Patients With Rheumatoid Arthritis (RA)

PHASE3CompletedINTERVENTIONAL
Enrollment

378

Participants

Timeline

Start Date

February 28, 2006

Primary Completion Date

March 31, 2013

Study Completion Date

March 31, 2013

Conditions
Rheumatoid Arthritis
Interventions
DRUG

rituximab [MabThera/Rituxan]

500mg iv in days 1 and 15, and 500mg iv on days 168 and 182

DRUG

rituximab [MabThera/Rituxan]

500mg iv on days 1 and 15, and 1000mg iv on days 168 and 182

DRUG

rituximab [MabThera/Rituxan]

1000mg iv on days 1 and 15 and 1000mg iv (or placebo in UK)on days 168 and 182

Trial Locations (91)

333

Taoyuan District

407

Taichung

1862

Diepkloof

2145

Sydney

2450

Coffs Harbour

3144

Malvern

3168

Melbourne

3300

Eger

4032

Debrecen

4215

Southport

4558

Maroochydore

7910

Timaru

7925

Cape Town

8022

Christchurch

9000

Ghent

10128

Turin

10330

Bangkok

10400

Bangkok

10700

Bangkok

16011

Arenzano

16132

Genoa

21000

Dijon

22081

Hamburg

24071

León

28006

Madrid

28007

Madrid

28905

Madrid

33076

Bordeaux

33394

Gijón

34295

Montpellier

37067

Valeggio sul Mincio

40002

Khon Kaen

40882

Ratingen

41014

Seville

42100

Reggio Emilia

44100

Ferrara

44652

Herne

46020

Pieve di Coriano

49074

Osnabrück

50200

Chiang Mai

50924

Cologne

53100

Siena

56100

Pisa

59037

Lille

59100

Prato

61231

Bad Nauheim

67100

Coppito

69120

Heidelberg

72037

Le Mans

75679

Paris

76233

Bois-Guillaume

85100

Potenza

90127

Palermo

90220

Oulu

100029

Beijing

100853

Beijing

74110010

Goiânia

04266-010

São Paulo

V2A 3G8

Penticton

V8V 3P9

Victoria

R3A 1M3

Winnipeg

N6A 4V2

London

L3Y 3R7

Newmarket

M5G 1X5

Toronto

G8Z 1Y2

Trois-Rivières

06202

Nice

1105 AZ

Amsterdam

2333 ZA

Leiden

6525 GA

Nijmegen

0620

Auckland

040 01

Košice

921 01

Piešťany

921 12

Piešťany

0083

Pretoria

08907

Barcelona

06006

Burgos

00833

Kaohsiung City

S75 2EP

Barnsley

B29 6JD

Birmingham

CB2 2QQ

Cambridge

G4 OSF

Glasgow

E11 1NR

London

BT47 6SB

Londonderry

M13 9WL

Manchester

CH49 5PE

Metropolitan Borough of Wirral

TS4 3BW

Middlesbrough

NN1 5BD

Northampton

NG5 1PB

Nottingham

RG1 5AN

Reading

TR1 3LJ

Truro

WN6 9EW

Wigan

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT00422383 - A Study of Retreatment With MabThera (Rituximab) in Combination With Methotrexate in Patients With Rheumatoid Arthritis (RA) | Biotech Hunter | Biotech Hunter