Study of Adalimumab Treatment for Induction and Maintenance of Clinical Remission in Subjects With Crohn's Disease

PHASE3CompletedINTERVENTIONAL
Enrollment

945

Participants

Timeline

Start Date

December 31, 2006

Primary Completion Date

July 31, 2008

Study Completion Date

July 31, 2008

Conditions
Crohn's Disease
Interventions
BIOLOGICAL

adalimumab

Adalimumab 40 mg Every Other Week dosing

BIOLOGICAL

adalimumab

Adalimumab 40 mg Every Week dosing if participant experiences a disease flare or is not responding to treatment. A disease flare is defined as an increase of 3 points or more on the HBI compared to the Baseline score and a total HBI score of 7 or higher. Non-response is defined as a decrease by fewer than 3 points in the HBI compared to Baseline.

Trial Locations (189)

1011

Site Ref # / Investigator 3322, Lausanne

1030

Site Ref # / Investigator 2978, Vienna

1060

Site Ref # / Investigator 2975, Vienna

1090

Site Ref # / Investigator 2976, Vienna

Site Ref # / Investigator 3021, Brussels

1200

Site Ref # / Investigator 3074, Brussels

2650

Site Ref # / Investigator 3020, Edegem

Site Ref # / Investigator 3076, Hvidovre

2820

Site Ref # / Investigator 3023, Bonheiden

3000

Site Ref # / Investigator 3773, Leuven

Site Ref # / Investigator 3088, Elsinore

3010

Site Ref # / Investigator 3321, Bern

4000

Site Ref # / Investigator 3022, Liège

4031

Site Ref # / Investigator 3323, Basel

5000

Site Ref # / Investigator 3019, Odense C

5021

Site Ref # / Investigator 3618, Bergen

8000

Site Ref # / Investigator 3037, Aarhus C

8036

Site Ref # / Investigator 3077, Graz

8091

Site Ref # / Investigator 3794, Zurich

8800

Site Ref # / Investigator 3047, Roeselare

9000

Site Ref # / Investigator 3625, Ghent

Site Ref # / Investigator 3075, Aalborg

10117

Site Ref # / Investigator 3096, Berlin

10367

Site Ref # / Investigator 3041, Berlin

11883

Site Ref # / Investigator 3896, Stockholm

12200

Site Ref # / Investigator 3070, Berlin

13015

Site Ref # / Investigator 3031, Marseille

13353

Site Ref # / Investigator 2980, Berlin

14033

Site Ref # / Investigator 2982, Caen

14089

Site Ref # / Investigator 3089, Berlin

15006

Site Ref # / Investigator 4660, Prague

17000

Site Ref # / Investigator 4659, Prague

18057

Site Ref # / Investigator 3095, Rostock

20089

Site Ref # / Investigator 3087, Rozzano

20097

Site Ref # / Investigator 3038, San Donato Milanese

20148

Site Ref # / Investigator 2981, Hamburg

Site Ref # / Investigator 3044, Hamburg

20157

Site Ref # / Investigator 3035, Milan

20246

Site Ref # / Investigator 2979, Hamburg

21682

Site Ref # / Investigator 3042, Stade

22185

Site Ref # / Investigator 3488, Lund

22297

Site Ref # / Investigator 3043, Hamburg

22559

Site Ref # / Investigator 3082, Hamburg

23538

Site Ref # / Investigator 3091, Lübeck

24105

Site Ref # / Investigator 3617, Kiel

25000

Site Ref # / Investigator 3012, Besançon

27100

Site Ref # / Investigator 3063, Pavia

28035

Site Ref # / Investigator 3484, Madrid

28040

Site Ref # / Investigator 2997, Madrid

28041

Site Ref # / Investigator 2999, Madrid

28046

Site Ref # / Investigator 3447, Madrid

28299

Site Ref # / Investigator 3595, Madrid

30625

Site Ref # / Investigator 3081, Hanover

31059

Site Ref # / Investigator 2986, Toulouse

32423

Site Ref # / Investigator 3050, Minden

33075

Site Ref # / Investigator 2993, Bordeaux

33203

Site Ref # / Investigator 2998, Cabuenes-Gijon

33600

Site Ref # / Investigator 3026, Pessac

34000

Site Ref # / Investigator 2994, Montpellier

35020

Site Ref # / Investigator 4383, Las Palmas de Gran Canaria

35128

Site Ref # / Investigator 3036, Padua

38043

Site Ref # / Investigator 3048, Grenoble

38126

Site Ref # / Investigator 3086, Braunschweig

39008

Site Ref # / Investigator 3000, Santander

39120

Site Ref # / Investigator 3090, Magdeburg

40138

Site Ref # / Investigator 3953, Bologna

41345

Site Ref # / Investigator 3895, Gothenburg

44035

Site Ref # / Investigator 3014, Nantes

44623

Site Ref # / Investigator 3093, Herne

44791

Site Ref # / Investigator 3084, Bochum

45500

Site Ref # / Investigator 4355, Ioannina

46010

Site Ref # / Investigator 3003, Valencia

48129

Site Ref # / Investigator 3056, Münster

48159

Site Ref # / Investigator 3057, Münster

48903

Site Ref # / Investigator 3005, Barakaldo

48960

Site Ref # / Investigator 2988, Galdakano

49076

Site Ref # / Investigator 3046, Osnabrück

50009

Site Ref # / Investigator 3007, Zaragoza

Site Ref # / Investigator 3010, Zaragoza

50134

Site Ref # / Investigator 3061, Florence

51092

Site Ref # / Investigator 3013, Reims

52351

Site Ref # / Investigator 3368, Düren

54511

Site Ref # / Investigator 3018, Vandœuvre-lès-Nancy

54642

Site Ref # / Investigator 4359, Thessaloniki

55116

Site Ref # / Investigator 3049, Mainz

55131

Site Ref # / Investigator 3083, Mainz

57010

Site Ref # / Investigator 4351, Thessaloniki

59037

Site Ref # / Investigator 3097, Lille

60318

Site Ref # / Investigator 3092, Frankfurt

62408

Site Ref # / Investigator 2983, Béthune

62500

Site Ref # / Investigator 3893, Brno

65100

Site Ref # / Investigator 3058, Pescara

67089

Site Ref # / Investigator 2973, Strasbourg

68161

Site Ref # / Investigator 3073, Mannheim

69120

Site Ref # / Investigator 3072, Heidelberg

69495

Site Ref # / Investigator 2974, Pierre-Bénite

70565

Site Ref # / Investigator 3045, Stuttgart

71100

Site Ref # / Investigator 4606, Heraklion

72108

Site Ref # / Investigator 2970, Rottenburg

75014

Site Ref # / Investigator 3017, Paris

75018

Site Ref # / Investigator 2995, Paris

75475

Site Ref # / Investigator 3025, Paris

75571

Site Ref # / Investigator 2996, Paris

75679

Site Ref # / Investigator 3016, Paris

75908

Site Ref # / Investigator 4275, Paris

76031

Site Ref # / Investigator 3024, Rouen

76133

Site Ref # / Investigator 3034, Karlsruhe

77520

Site Ref # / Investigator 4657, Olomouc

80054

Site Ref # / Investigator 3032, Amiens

80131

Site Ref # / Investigator 3065, Naples

80639

Site Ref # / Investigator 3098, Munich

81377

Site Ref # / Investigator 3055, Munich

81925

Site Ref # / Investigator 3054, Munich

83183

Site Ref # / Investigator 3892, Östersund

85221

Site Ref # / Investigator 2972, Dachau

90146

Site Ref # / Investigator 3062, Palermo

91014

Site Ref # / Investigator 3027, Évry

92110

Site Ref # / Investigator 3015, Clichy

92701

Site Ref # / Investigator 3011, Colombes

93053

Site Ref # / Investigator 3078, Regensburg

93370

Site Ref # / Investigator 2985, Montfermeil

94010

Site Ref # / Investigator 3030, Créteil

Site Ref # / Investigator 3033, Créteil

A-4600

Site Ref # / Investigator 2977, Wels

05850

Site Ref # / Investigator 3623, Hyvinkää

06202

Site Ref # / Investigator 3029, Nice

D-86156

Site Ref # / Investigator 2969, Augsburg

D-44789

Site Ref # / Investigator 3051, Bochum

D-03048

Site Ref # / Investigator 3094, Cottbus

01067

Site Ref # / Investigator 3053, Dresden

D-91054

Site Ref # / Investigator 3052, Erlangen

D-45239

Site Ref # / Investigator 3085, Essen

D-79106

Site Ref # / Investigator 3040, Freiburg im Breisgau

06120

Site Ref # / Investigator 3066, Halle

07747

Site Ref # / Investigator 3080, Jena

04103

Site Ref # / Investigator 3071, Leipzig

D-70376

Site Ref # / Investigator 3079, Stuttgart

106 76

Site Ref # / Investigator 4352, Athens

106-76

Site Ref # / Investigator 4357, Athens

124 62

Site Ref # / Investigator 4358, Athens

184 54

Site Ref # / Investigator 4353, Nikaia

Unknown

Site Ref # / Investigator 3326, Cork

Site Ref # / Investigator 3324, Dublin

Site Ref # / Investigator 3325, Dublin

00133

Site Ref # / Investigator 3064, Rome

00152

Site Ref # / Investigator 2991, Rome

00186

Site Ref # / Investigator 3039, Rome

N-8092

Site Ref # / Investigator 3629, Bodø

N-2326

Site Ref # / Investigator 3630, Hamar

0370

Site Ref # / Investigator 3620, Oslo

0514

Site Ref # / Investigator 3619, Oslo

4700-308

Site Ref # / Investigator 3596, Braga

3000-075

Site Ref # / Investigator 3069, Coimbra

1150-069

Site Ref # / Investigator 4972, Lisbon

1649-035

Site Ref # / Investigator 3068, Lisbon

SK-813 69

Site Ref # / Investigator 3493, Bratislava

04001

Site Ref # / Investigator 4626, Košice

08001

Site Ref # / Investigator 3494, Prešov

03010

Site Ref # / Investigator 3448, Alicante

08916

Site Ref # / Investigator 3009, Badalona - Barcelona

08003

Site Ref # / Investigator 2990, Barcelona

08035

Site Ref # / Investigator 2989, Barcelona

08036

Site Ref # / Investigator 3002, Barcelona

08097

Site Ref # / Investigator 3486, Barcelona

07014

Site Ref # / Investigator 3008, Palma de Mallorca

416 85

Site Ref # / Investigator 3500, Gothenburg

581 85

Site Ref # / Investigator 3499, Linköping

541 85

Site Ref # / Investigator 3498, Skövde

114 86

Site Ref # / Investigator 3489, Stockholm

171 76

Site Ref # / Investigator 3487, Stockholm

901 85

Site Ref # / Investigator 3594, Umeå

EX31 4JB

Site Ref # / Investigator 4604, Barnstaple

CF14 4XW

Site Ref # / Investigator 4590, Cardiff

DD1 9SY

Site Ref # / Investigator 4603, Dundee

EH4 2XU

Site Ref # / Investigator 4579, Edinburgh

HA1 3UJ

Site Ref # / Investigator 4588, Harrow

L7 8XP

Site Ref # / Investigator 4586, Liverpool

NW1 2BU

Site Ref # / Investigator 4595, London

SE1 7EH

Site Ref # / Investigator 4607, London

SE5 9RS

Site Ref # / Investigator 4596, London

W12 ONN

Site Ref # / Investigator 4580, London

NG7 2UH

Site Ref # / Investigator 4591, Nottingham

PL6 8DH

Site Ref # / Investigator 4589, Plymouth

PO6 3LY

Site Ref # / Investigator 4592, Portsmouth

S60 2UD

Site Ref # / Investigator 4597, Rotherham

S10 2JF

Site Ref # / Investigator 4584, Sheffield

SO16 6YD

Site Ref # / Investigator 4578, Southampton

SK2 7JE

Site Ref # / Investigator 4598, Stockport

CR7 7YE

Site Ref # / Investigator 4581, Surrey

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Abbott

INDUSTRY