Rheumatoid Arthritis: Comparison of Active Therapies in Patients With Active Disease Despite Methotrexate Therapy

NACompletedINTERVENTIONAL
Enrollment

353

Participants

Timeline

Start Date

July 31, 2007

Primary Completion Date

December 31, 2011

Study Completion Date

May 31, 2012

Conditions
Rheumatoid Arthritis
Interventions
DRUG

Etanercept

etanercept, subcutaneous injection

DRUG

methotrexate

baseline methotrexate is maintained throughout the study and is not provided by the sponsor

DRUG

Sulfasalazine

sulfasalazine, oral

DRUG

Hydroxychloroquine

hydroxychloroquine, oral

DRUG

Placebo, triple

Participants in Etanercept arm (Arm 1) were given placebo hydroxychloroquine and sulfasalazine pills.

DRUG

Placebo, etanercept

Participants in triple arm (Arm 2) were given placebo etanercept injections.

Trial Locations (37)

15240

VA Pittsburgh Health Care System, Pittsburgh

16801

Geisinger Medical Group - State College, State College

17822

Geisinger Medical Center, Danville

18711

Geisinger Medical Group- Wilkes Barre, Wyoming Valley

19104

VA Medical Center, Philadelphia, Philadelphia

20422

VA Medical Center, DC, Washington D.C.

55417

Park Nicollet (RAIN), Minneapolis

VA Medical Center, Minneapolis, Minneapolis

55804

St. Mary's/ Duluth Clinic Health System (RAIN), Duluth

55905

Mayo Clinic, Rochester

57701

Rapid City Medical Center (RAIN), Rapid City

58102

VA Medical Center, Fargo, Fargo

58501

Bone, Spine Sports Clinic (RAIN), Bismarck

63106

VA Medical Center, St Louis, St Louis

68198

Univesity of Nebraska Medical Center, Omaha

68506

Lincoln Medical Center, Lincoln

75216

VA North Texas Health Care System, Dallas, Dallas

84148

VA Salt Lake City Health Care System, Salt Lake City, Salt Lake City

90822

VA Medical Center, Long Beach, Long Beach

91343

VA Greater Los Angeles HCS, Sepulveda, Sepulveda

92357

VA Medical Center, Loma Linda, Loma Linda

94121

VA Medical Center, San Francisco, San Francisco

97201

VA Medical Center, Portland, Portland

93454-6945

Pacific Arthritis Center (RAIN), Santa Maria

68105-1873

VA Medical Center, Omaha, Omaha

29401-5799

Ralph H Johnson VA Medical Center, Charleston, Charleston

57117-5046

Avera Research Institute (RAIN), Sioux Falls

05009-0001

VA Medical & Regional Office Center, White River, White River Junction

T2N 4N1

University of Calgary (CRRC), Calgary

R3A 1M4

University of Manitoba (CRRC), Winnipeg

L6T 3J1

Brampton (CRRC), Brampton

L5M 2V8

Credit Valley Rheumatology, Missassauga

L3Y 3R7

Newmarket (CRRC), Newmarket

M5T 3L9

Mount Sinai Hospital (CRRC), Toronto

N8X 5A6

Clinical Research and Arthritis Center, Windsor

H2L 4M1

Hopital Notre Dame (CRRC), Montreal

J1H 5N4

Crc-Chus (Crrc), Sherbrooke

All Listed Sponsors
collaborator

Canadian Institutes of Health Research (CIHR)

OTHER_GOV

collaborator

Rheumatoid Arthritis Investigational Network (RAIN)

UNKNOWN

collaborator

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

NIH

lead

US Department of Veterans Affairs

FED

NCT00405275 - Rheumatoid Arthritis: Comparison of Active Therapies in Patients With Active Disease Despite Methotrexate Therapy | Biotech Hunter | Biotech Hunter