Effects of a Range of Naltrexone Doses in Combination With Smoked Marijuana

PHASE2CompletedINTERVENTIONAL
Enrollment

49

Participants

Timeline

Start Date

December 31, 2006

Primary Completion Date

May 31, 2008

Study Completion Date

August 31, 2010

Conditions
Marijuana Use
Interventions
DRUG

Placebo + Inactive Marijuana (0% THC)

One capsule containing placebo was administered to the participant in a size 00 opaque capsules with lactose filler 45 minutes before marijuana administration.

DRUG

Placebo + Active Marijuana (3.27% THC)

One capsule containing placebo was administered to the participant in a size 00 opaque capsules with lactose filler 45 minutes before administration of a marijuana cigarette containing 3.27% THC (ca. 800 mg) provided by the National Institute on Drug Abuse.

DRUG

Naltrexone 12 Mg+ Active Marijuana (3.27% THC)

One capsule containing 12mg Naltrexone was administered to the participant in a size 00 opaque capsules with lactose filler 45 minutes before active marijuana administration.

DRUG

Naltrexone 25 Mg + Active Marijuana (3.27% THC)

One capsule containing 12mg Naltrexone was administered to the participant in a size 00 opaque capsules with lactose filler 45 minutes before active marijuana administration.

DRUG

Naltrexone 50 Mg+ Active Marijuana (3.27% THC)

One capsule containing 25mg Naltrexone was administered to the participant in a size 00 opaque capsules with lactose filler 45 minutes before marijuana administration.

DRUG

Naltrexone 100 Mg+ Active Marijuana (3.27% THC)

One capsule containing 50mg Naltrexone was administered to the participant in a size 00 opaque capsules with lactose filler 45 minutes before marijuana administration.

DRUG

Naltrexone 12 Mg + Inactive Marijuana (0% THC)

One capsule containing 12mg Naltrexone was administered to the participant in a size 00 opaque capsules with lactose filler 45 minutes before inactive marijuana administration.

DRUG

Naltrexone 25 Mg + Inactive Marijuana (0% THC)

One capsule containing 25mg Naltrexone was administered to the participant in a size 00 opaque capsules with lactose filler 45 minutes before inactive marijuana administration.

DRUG

Naltrexone 50 Mg + Inactive Marijuana (0% THC)

One capsule containing 50mg Naltrexone was administered to the participant in a size 00 opaque capsules with lactose filler 45 minutes before inactive marijuana administration.

DRUG

Naltrexone 100 Mg + Inactive Marijuana (0% THC)

One capsule containing 100mg Naltrexone was administered to the participant in a size 00 opaque capsules with lactose filler 45 minutes before inactive marijuana administration.

All Listed Sponsors
collaborator

Research Foundation for Mental Hygiene, Inc.

OTHER

collaborator

National Institute on Drug Abuse (NIDA)

NIH

lead

New York State Psychiatric Institute

OTHER

NCT00403117 - Effects of a Range of Naltrexone Doses in Combination With Smoked Marijuana | Biotech Hunter | Biotech Hunter