A Phase 1/2 Study Of HKI-272 (Neratinib) in Combination With Trastuzumab (Herceptin) In Subjects With Advanced Breast Cancer

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

45

Participants

Timeline

Start Date

April 4, 2007

Primary Completion Date

July 31, 2009

Study Completion Date

March 2, 2018

Conditions
Advanced Breast Cancer
Interventions
DRUG

HKI-272

HKI-272 by mouth

DRUG

trastuzumab

trastuzumab 4 mg/kg IV as a loading dose followed by trastuzumab 2 mg/kg weekly thereafter

Trial Locations (14)

19111

Fox Chase Cancer Center, Philadelphia

21201

University of Maryland, University of Maryland Medical Center, Baltimore

27710

Duke University, Duke University Medical Center, Durham

44805

Centre Rene Gauducheau, Saint-Herblain

75005

Institut Curie, Paris

90033

LAC/USC Medical Center, USC/Norris Comprehensive Cancer Center, Los Angeles

91105

City of Hope National Medical Center, Pasadena

100021

Cancer Hospital, Academy of Med Science and Peking Union Med, Beijing

100071

307 Hospital of Chinese People's Liberation Army, Beijing

100853

Chinese PLA General Hospital, Beijing

210002

Chinese Nanjing Bayi Hospital, Nanjing

300121

Tianjin Union Medicine Center, Tianjin

91010-3000

City of Hope National Medical Center, Duarte

CH-1011

Centre Hospitalier Universitaire Vaudois, Lausanne

All Listed Sponsors
lead

Puma Biotechnology, Inc.

INDUSTRY

NCT00398567 - A Phase 1/2 Study Of HKI-272 (Neratinib) in Combination With Trastuzumab (Herceptin) In Subjects With Advanced Breast Cancer | Biotech Hunter | Biotech Hunter