226
Participants
Start Date
October 31, 2006
Primary Completion Date
June 30, 2013
Study Completion Date
May 31, 2015
Interventional therapy
All interventional procedures are standard of care for the treatment of AVMs. They are not experimental. A patient randomized to interventional therapy is expected to begin interventional therapy within 3 months following randomization. Interventional therapy consists of endovascular attempts at occlusion of the nidus and feeding vessels, coiling or microsurgery for feeding artery aneurysms, microsurgery for BAVM itself, and radiosurgery, these alone or in various combinations and timings.
Medical management
Patients participating in the trial will receive the best medical management possible for the disorder being tested in the trial and for any general medical illnesses they are demonstrated to have. One important consideration in the medical management of patients in this trial is stroke risk factor reduction.
Austin Health, University of Melbourne 300 Waterdale Rd,Heidelberg Heights, Melbourne
Wesley Medical Center, Auchenflower
Department of Neurosurgery, Universitair Medisch Centrum Groningen Hanzeplein 1, Groningen
Mount Sinai Hospital, One Gustave L. Levy Place, Department of Neurosurgery- Box 1136, New York
New York Presbyterian Hospital, Columbia Campus, Neurological Institute, 710 W. 168th St, New York
Long Island Jewish Medical Center, New Hyde Park
Winthrop University Hospital, Mineola
Charité Campus Benjamin Franklin (CCBF), Neurologische Klinik, Hindenburgdamm 30, Berlin
Mercy Hospital of Buffalo, Buffalo
John P. Murtha Neuroscience & Pain Institute,1450 Scapl Ave, Suite 120,, Johnstown
Thomas Jefferson Hospital for Neuroscience, Philadelphia
Servizio di Neuroradiologia, Ospedale San Raffaele, Via Olgettina 60, Milan
Department of Neuroradiology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg
University of Virginia School of Medicine, Department of Neurosurgery, P.O. Box 800212, Charlottesville
Sentara Medical Group, Norfolk
Hôpital de la Cavale-Blanche, Service de Neurologie, Bd. Tanguy Pringent, Brest
University of Miami, Miami
Bellaria Hospital, Department of Neurosurgery, Bologna
Universitätsklinikum Essen, Institut für Diagnostische und Interventionelle Radiologie und Neuroradiologie, Hufelandstraße 55, Essen
Michigan Head and Spine Institute, Providence Hospital and Medical Center, 16001 West Nine Mile Road, Southfield
Marshfield Clinic, Marshfield
Centre Hospitalier Régional et Universitaire de Lille, Clinique de Neurochirurgie, Hopital Roger Salengro, CHRU, Lille
Uniklinikum Frankfurt, Institut für Neuroradiologie, Schleusenweg 2-16, Frankfurt am Main
Rush University Medical Center, Chicago
Universitätsklinik Heidelberg, Department of Neurosurgery, Im Neuenheimer Feld 400, Heidelberg
Hôpital Sainte Anne, Service de Neurochirurgie, Centre Hospitalier Sainte Anne, 1, Rue Cabanis, Paris
Hôpital Lariboisière, Service de Neuroradiologie, 2, Rue Ambroise Paré, Paris
University of Texas Medical School in Houston, Houston
Brackenridge Hospital, Brain and Spine Center, 601 East 15th Street, Austin
Uniklinik Freiburg, Neuroradiology-Neurocenter, Breisacher Str. 64, Freiburg im Breisgau
Klinikum Großhadern, LMU München, Neurologische Klinik und Poliklinik, Marchionistr. 15, Munich
Barrow Neurological Institute, 350 West Thomas Road, Phoenix
Kaiser Permanente Los Angeles Medical Center,4867 Sunset Blvd, Los Angeles
CHU Henri Mondor, Service de Neuroradiologie, Créteil
Kaiser Permanente (SF), Redwood City
University of California at San Francisco, 1001 Potrero Avenue- Rm 3C-38, San Francisco
University of California at Los Angeles, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles
Loyola University Stritch School of Medicine, Department of Neurology, 2160 S 1st Ave, Bldg 105/2700, Maywood
University of Iowa Hospitals, Department of Neurology, 200 Hawkins Drive ,, Iowa City
St. Joseph's Regional Medical Center, Paterson
SUNY Downstate Medical Center, 451 Clarkson Avenue, Box 1189, Brooklyn
Medical College of Wisconsin, Milwaukee
Universitätsklinik für Neurologie, Anichstrasse 35, 6020 Innsbruck, Innsbruck
Rudolfstiftung, Neurochirurgie, Juchgasse 25, A-1030, Vienna
Hospital de Clinicas de Porto Alegre, Porto Alegre
European Coordinating Center: Dept. of Neurology, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75475 Paris cedex 10,, Paris
Utrecht University Hospital, Heidelberglaan 100, 3584 CX, Utrecht
Inselspital, Neurologische Klinik, 3010 Bern, Schweiz
Hamilton General Hospital .237 Barton Street East, Hamilton
London Health Sciences Center, London
CHUM Notre Dame Hospital, Department of Radiology, 1560 Sherbrooke Street, Montreal
Helsinki University Central Hospital, Dept. of Neurosurgery, Topeliuksenkatu 5, Helsinki, P.O. Box 266, Helsinki
Uniklinikum Dresden, Neuroradiologie, Fetscherstr. 74, Dresden
Berufsgenossenschaftliche Kliniken Bergmannstrost, Klinik für Neurochirurgie, Merseburger Str. 165, Halle
Seoul National University Hospital, Seoul
Hospital Universitari de Bellvitge, Sección de Neuroradiologia, c/ Feixa Llarga s/n, L'Hospitalet de Llobregat, Barcelona
Frenchay Hospital, Neuroradiology Department, Bristol
Western General Hospital, Bramwell Dott Building, Department of Clinical Neurosciences, Crewe Road, Edinburgh
Consultant Neurologist, Department of Neurology, Leeds General Infirmary, Great George Street, Leeds
Walton Centre for Neurology, Lower Lane Fazakerley, Liverpool
Institute of Neurology, Box 6, The National Hospital, Queen Square, London
Department of Neurosurgery, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne
Imaging Directorate, Derriford Hospital, Plymouth
Neuroscience Department, Royal Preston Hospital, Sharoe Green Lane, Fulwood, Preston
Department of Neurology, Hope Hospital, Salford
Department of Neurology, Royal Hallamshire Hospital, Glossop Road, Sheffield
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Columbia University
OTHER