Bortezomib and Topotecan in Treating Patients With Advanced Solid Tumors

PHASE1CompletedINTERVENTIONAL
Enrollment

24

Participants

Timeline

Start Date

December 31, 2004

Primary Completion Date

November 30, 2007

Study Completion Date

June 30, 2008

Conditions
Lung CancerUnspecified Adult Solid Tumor, Protocol Specific
Interventions
DRUG

bortezomib

Dose level A: 1 mg/m2; Dose level B: 1.3 mg/m2; Dose level C: 1.6 mg/m2; Dose level D: 1.6 mg/m2

DRUG

topotecan hydrochloride

Dose level A: 3 mg/m2; Dose level B: 3 mg/m2; Dose level C: 3 mg/m2; Dose level D: 4 mg/m2

OTHER

flow cytometry

No description

OTHER

immunoenzyme technique

No description

OTHER

immunohistochemistry staining method

No description

OTHER

laboratory biomarker analysis

No description

Trial Locations (1)

95817

University of California Davis Cancer Center, Sacramento

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

University of California, Davis

OTHER

NCT00388089 - Bortezomib and Topotecan in Treating Patients With Advanced Solid Tumors | Biotech Hunter | Biotech Hunter