A Type 2 Diabetes Study of the Longer-Term Glycemic Effect of AVANDAMET vs. Metformin

PHASE4CompletedINTERVENTIONAL
Enrollment

688

Participants

Timeline

Start Date

October 31, 2006

Primary Completion Date

September 30, 2009

Study Completion Date

September 30, 2009

Conditions
Diabetes Mellitus, Type 2
Interventions
DRUG

Avandamet 6 mg/1500 mg (ttd)

One 2 mg/ 500 mg capsule will be taken in the AM with the morning meal Two 2 mg/ 500 mg capsules will be taken in the PM with the evening meal

DRUG

Avandamet 4 mg/1000 mg (ttd)

One 2 mg/500 mg capsule will be taken in the AM with the morning meal. One 2 mg/500 mg capsule will be taken in the PM with the evening meal.

DRUG

Avandamet 2 mg/500 mg (ttd)

one placebo capsule will be taken in the AM with the morning meal one 2 mg/ 500 mg capsule will be taken in the PM with the evening meal.

DRUG

Avandamet 8 mg/ 2000 mg (ttd)

Two 2 mg/ 500 mg capsules will be taken in the AM with the morning meal. Two 2 mg/ 500 mg capsules will be taken in the PM with the evening meal.

DRUG

Metformin 500 mg (ttd)

One placebo capsule will be taken in the AM with the morning meal. One 500 mg capsule will be taken in the PM with the evening meal.

DRUG

Metformin 1000 mg (ttd)

One 500 mg capsule will be taken in the AM with the morning meal. One 500 mg capsule will be taken in the PM with the evening meal.

DRUG

Metformin 1500 mg (ttd)

One 500 mg capsule will be taken in the AM with the morning meal. Two 500 mg capsules will be taken in the PM with the evening meal.

DRUG

Metformin 2000 mg (ttd)

Two 500 mg capsule will be taken in the AM with the morning meal. Two 500 mg capsule will be taken in the PM with the evening meal.

Trial Locations (116)

114

GSK Investigational Site, Taipei

333

GSK Investigational Site, Taoyuan Hsien

404

GSK Investigational Site, Taichung

500

GSK Investigational Site, Changhua

833

GSK Investigational Site, Kaohsiung City

1000

GSK Investigational Site, Manila

1008

GSK Investigational Site, Manila

1108

GSK Investigational Site, Quezon City

1425

GSK Investigational Site, Buenos Aires

1810

GSK Investigational Site, Marikina City

5000

GSK Investigational Site, Córdoba

5500

GSK Investigational Site, Mendoza

6000

GSK Investigational Site, Cebu City

11355

GSK Investigational Site, Flushing

12401

GSK Investigational Site, Kingston

13057

GSK Investigational Site, East Syracuse

15009

GSK Investigational Site, Beaver

15143

GSK Investigational Site, Sewickley

15205

GSK Investigational Site, Clairton

16508

GSK Investigational Site, Erie

19320

GSK Investigational Site, Coatsville

19382

GSK Investigational Site, West Chester

20110

GSK Investigational Site, Manassas

21075

GSK Investigational Site, Elkridge

22015

GSK Investigational Site, Burke

22320

GSK Investigational Site, Tijuana

24153

GSK Investigational Site, Salem

28078

GSK Investigational Site, Huntersville

29201

GSK Investigational Site, Columbia

29325

GSK Investigational Site, Clinton

29669

GSK Investigational Site, Pelzer

33013

GSK Investigational Site, Hialeah

34070

GSK Investigational Site, Durango

34471

GSK Investigational Site, Ocala

35406

GSK Investigational Site, Tuscaloosa

37660

GSK Investigational Site, Kingsport

42039

GSK Investigational Site, Pachuca

43210

GSK Investigational Site, Columbus

44195

GSK Investigational Site, Cleveland

44260

GSK Investigational Site, Mogadore

44281

GSK Investigational Site, Wandsworth

44614

GSK Investigational Site, Canal Fulton

44718

GSK Investigational Site, Canton

45429

GSK Investigational Site, Kettering

46123

GSK Investigational Site, Avon

46254

GSK Investigational Site, Indianapolis

47710

GSK Investigational Site, Evansville

47712

GSK Investigational Site, Evansville

50702

GSK Investigational Site, Waterloo

53228

GSK Investigational Site, Wauwatosa

54000

GSK Investigational Site, Lahore

55318

GSK Investigational Site, Chaska

59102

GSK Investigational Site, Billings

61615

GSK Investigational Site, Peoria

63110

GSK Investigational Site, St Louis

63128

GSK Investigational Site, St Louis

63376

GSK Investigational Site, City of Saint Peters

64024

GSK Investigational Site, Excelsior Springs

64460

GSK Investigational Site, Monterrey

70461

GSK Investigational Site, Slidell

70584

GSK Investigational Site, Sunset

74800

GSK Investigational Site, Karachi

75235

GSK Investigational Site, Dallas

78404

GSK Investigational Site, Corpus Christi

78626

GSK Investigational Site, Georgetown

80033

GSK Investigational Site, Wheat Ridge

85020

GSK Investigational Site, Phoenix

85296

GSK Investigational Site, Gilbert

85308

GSK Investigational Site, Glendale

85712

GSK Investigational Site, Tucson

85745

GSK Investigational Site, Tucson

87102

GSK Investigational Site, Albuquerque

89016

GSK Investigational Site, Las Vegas

89048

GSK Investigational Site, Pahrump

90701

GSK Investigational Site, Artesia

91801

GSK Investigational Site, Alhambra

94904

GSK Investigational Site, Greenbrae

95661

GSK Investigational Site, Roseville

95825

GSK Investigational Site, Sacramento

96732

GSK Investigational Site, Kahului

97045

GSK Investigational Site, Oregon City

98335

GSK Investigational Site, Gig Harbor

98338

GSK Investigational Site, Graham

98405

GSK Investigational Site, Tacoma

98506

GSK Investigational Site, Olympia

98664

GSK Investigational Site, Vancouver

98801

GSK Investigational Site, Wenatchee

55407-3799

GSK Investigational Site, Minneapolis

08690

GSK Investigational Site, Hamilton

05403

GSK Investigational Site, South Burlington

C1425AWC

GSK Investigational Site, Buenos Aries

C1416DRJ

GSK Investigational Site, Capital Federal

B1704ETD

GSK Investigational Site, Ciudad Autonoma de Buenos Aires

C1155ADP

GSK Investigational Site, Ciudad Autonoma de Buenos Aires

C1117ABH

GSK Investigational Site, Buenos Aires

60120-021

GSK Investigational Site, Fortaleza

74110-010

GSK Investigational Site, Goiânia

90035-170

GSK Investigational Site, Porto Alegre

13073-350

GSK Investigational Site, Campinas

01323-001

GSK Investigational Site, São Paulo

71625-009

GSK Investigational Site, Brasília

V3K 3P4

GSK Investigational Site, Coquitlam

E2A 4X7

GSK Investigational Site, Bathurst

A0A 1G0

GSK Investigational Site, Bay Roberts

A1E 2C2

GSK Investigational Site, St. John's

L6T 3T1

GSK Investigational Site, Brampton

K7A 4W8

GSK Investigational Site, Smiths Falls

M9W 4L6

GSK Investigational Site, Toronto

J8Y 6S8

GSK Investigational Site, Gatineau

J1H 4J6

GSK Investigational Site, Sherbrooke

501-757

GSK Investigational Site, Gwangju

110-749

GSK Investigational Site, Seoul

139-872

GSK Investigational Site, Seoul

152-703

GSK Investigational Site, Seoul

443-721

GSK Investigational Site, Suwon, Kyonggi-do

480-130

GSK Investigational Site, Uijeongbu-si, Kyonggi-do

Sponsors

Lead Sponsor

All Listed Sponsors
lead

GlaxoSmithKline

INDUSTRY