52
Participants
Start Date
July 31, 2005
Primary Completion Date
August 31, 2016
Study Completion Date
August 31, 2016
Gemcitabine
800 mg/m\^2 IV over 30 minutes on Day -7 (1 day)
Fludarabine
33 mg/m\^2 IV over 30 minutes Day -5 to Day -2 (4 days)
Melphalan
70 mg/m\^2 IV over 30 minutes on Day -3 to Day -2 (2 days)
Antithymocyte Globulin
"2 mg/kg IV on Day -4 and Day -3 (2 days) before stem cell transplantation.~If receiving transplant from matched unrelated donor (not a blood relative), a mismatched related donor (a blood relative, but not a full match), or receiving a cord blood transplant."
Allogeneic Stem Cell Infusion
Infusion of stem cells on Day 0.
Tacrolimus
0.03 mg/kg beginning Day -2 by vein over 24 hours; when tolerable change to pill form given once daily for 3-4 months.
Filgrastim (G-CSF)
Starting 1 week after transplant (Day +7) given as injection under the skin once daily until blood cell levels return to normal.
Methotrexate
5 mg/m2 by vein on Days +1, +3, +6, and +11 to decrease risk of GVHD.
University of Texas MD Anderson Cancer Center, Houston
M.D. Anderson Cancer Center
OTHER