QOL-Stereotactic RadioSurgery, Temozolomide + Erlotinib-Rx of 1-3 Brain Metastases in NSCLC

PHASE2WithdrawnINTERVENTIONAL
0
Timeline

Start Date

July 31, 2008

Primary Completion Date

December 31, 2008

Study Completion Date

December 31, 2008

Conditions
Lung CancerMetastatic Cancer
Interventions
DRUG

erlotinib hydrochloride

Erlotinib will be administered orally on at a dose of 200 mg/day on Days 1-23 of each 28 day cycle.

DRUG

temozolomide

Temozolomide will be administered orally at a dose of 150 mg/m2 on Days 1-5 for Cycle 1 then increased to 200 mg/m2 for Cycle 2 forward.

RADIATION

stereotactic radiosurgery

Stereotactic radiosurgery will be performed prior to chemotherapy.

Sponsors
All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

collaborator

Schering-Plough

INDUSTRY

collaborator

Genentech, Inc.

INDUSTRY

lead

University of Medicine and Dentistry of New Jersey

OTHER