Combination Chemotherapy and Cetuximab in Treating Patients With Metastatic Esophageal Cancer or Gastroesophageal Junction Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

245

Participants

Timeline

Start Date

September 15, 2006

Primary Completion Date

April 30, 2011

Study Completion Date

October 15, 2014

Conditions
Esophageal Cancer
Interventions
BIOLOGICAL

cetuximab

given IV

DRUG

ECF

epirubicin and 5-fluorouracil given IV

DRUG

IC

cisplatin and irinotecan given IV

DRUG

FOLFOX

oxaliplatin , leucovorin and 5-fluorouracil IV

Trial Locations (227)

10035

Ralph Lauren Center for Cancer Care and Prevention, New York

10065

Memorial Sloan-Kettering Cancer Center, New York

10466

Our Lady of Mercy Medical Center Comprehensive Cancer Center, The Bronx

12801

Charles R. Wood Cancer Center at Glens Falls Hospital, Glens Falls

13057

CCOP - Hematology-Oncology Associates of Central New York, East Syracuse

14215

Veterans Affairs Medical Center - Buffalo, Buffalo

16801

Geisinger Medical Group - Scenery Park, State College

16803

Mount Nittany Medical Center, State College

17044

Lewistown Hospital, Lewistown

17701

Susquehanna Cancer Center at Divine Providence Hospital, Williamsport

18015

St. Luke's Cancer Network at St. Luke's Hospital, Bethlehem

18105

Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest, Allentown

18201

Geisinger Hazleton Cancer Center, Hazleton

18301

Dale and Frances Hughes Cancer Center at Pocono Medical Center, East Stroudsburg

18508

Hematology and Oncology Associates of Northeastern Pennsylvania, Scranton

18711

Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center, Wilkes-Barre

18765

Mercy Hospital at Wilkes-Barre, Wilkes-Barre

19107

Joan Karnell Cancer Center at Pennsylvania Hospital, Philadelphia

19114

Frankford Hospital Cancer Center - Torresdale Campus, Philadelphia

19713

CCOP - Christiana Care Health Services, Newark

19958

Tunnell Cancer Center at Beebe Medical Center, Lewes

20007

Lombardi Comprehensive Cancer Center at Georgetown University Medical Center, Washington D.C.

21237

Harry and Jeanette Weinberg Cancer Institute at Franklin Square Hospital Center, Baltimore

21601

Shore Regional Cancer Center at Memorial Hospital - Easton, Easton

21921

Union Hospital of Cecil County, Elkton

24273

Southwest Virginia Regional Cancer Center at Wellmonth Health, Norton

24541

Danville Regional Medical Center, Danville

27534

Wayne Memorial Hospital, Incorporated, Goldsboro

28501

Kinston Medical Specialists, Kinston

28791

Pardee Memorial Hospital, Hendersonville

29501

McLeod Regional Medical Center, Florence

37662

Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center, Kingsport

44109

MetroHealth Cancer Care Center at MetroHealth Medical Center, Cleveland

45801

St. Rita's Medical Center, Lima

46202

William N. Wishard Memorial Hospital, Indianapolis

46350

Center for Cancer Therapy at LaPorte Hospital and Health Services, La Porte

46360

Saint Anthony Memorial Health Centers, Michigan City

46515

Elkhart General Hospital, Elkhart

46601

CCOP - Northern Indiana CR Consortium, South Bend

Memorial Hospital of South Bend, South Bend

46617

Saint Joseph Regional Medical Center, South Bend

South Bend Clinic, South Bend

46845

Fort Wayne Medical Oncology and Hematology, Fort Wayne

46904

Howard Community Hospital, Kokomo

48060

Mercy Regional Cancer Center at Mercy Hospital, Port Huron

48093

St. John Macomb Hospital, Warren

48106

CCOP - Michigan Cancer Research Consortium, Ann Arbor

48154

St. Mary Mercy Hospital, Livonia

48236

Van Elslander Cancer Center at St. John Hospital and Medical Center, Grosse Pointe Woods

48503

Genesys Hurley Cancer Institute, Flint

Hurley Medical Center, Flint

48601

Seton Cancer Institute at Saint Mary's - Saginaw, Saginaw

49001

Borgess Medical Center, Kalamazoo

49007

Bronson Methodist Hospital, Kalamazoo

49085

Lakeland Regional Cancer Care Center - St. Joseph, Saint Joseph

Oncology Care Associates, PLLC, Saint Joseph

49201

Foote Memorial Hospital, Jackson

49431

Green Bay Oncology, Limited - Escanaba, Escanaba

49801

Dickinson County Healthcare System, Iron Mountain

50010

McFarland Clinic, PC, Ames

50266

Medical Oncology and Hematology Associates - West Des Moines, West Des Moines

50307

Mercy Capitol Hospital, Des Moines

50309

CCOP - Iowa Oncology Research Association, Des Moines

John Stoddard Cancer Center at Iowa Methodist Medical Center, Des Moines

Medical Oncology and Hematology Associates at John Stoddard Cancer Center, Des Moines

50314

Medical Oncology and Hematology Associates at Mercy Cancer Center, Des Moines

Mercy Cancer Center at Mercy Medical Center - Des Moines, Des Moines

50316

John Stoddard Cancer Center at Iowa Lutheran Hospital, Des Moines

50401

Mercy Cancer Center at Mercy Medical Center - North Iowa, Mason City

51101

Siouxland Hematology-Oncology Associates, LLP, Sioux City

51104

Mercy Medical Center - Sioux City, Sioux City

St. Luke's Regional Medical Center, Sioux City

52403

Cedar Rapids Oncology Associates, Cedar Rapids

Mercy Regional Cancer Center at Mercy Medical Center, Cedar Rapids

52501

McCreery Cancer Center at Ottumwa Regional, Ottumwa

52722

Hematology Oncology Associates of the Quad Cities, Bettendorf

53215

Medical Consultants, Limited, Milwaukee

54143

Bay Area Cancer Care Center at Bay Area Medical Center, Marinette

54154

Green Bay Oncology, Limited - Oconto Falls, Oconto Falls

54235

Green Bay Oncology, Limited - Sturgeon Bay, Sturgeon Bay

54303

Green Bay Oncology, Limited at St. Mary's Hospital, Green Bay

St. Mary's Hospital Medical Center - Green Bay, Green Bay

54401

Marshfield Clinic - Wausau Center, Wausau

University of Wisconcin Cancer Center at Aspirus Wausau Hospital, Wausau

54449

Saint Joseph's Hospital, Marshfield

54476

Marshfield Clinic - Weston Center, Weston

54481

Saint Michael's Hospital Cancer Center, Stevens Point

54494

Marshfield Clinic - Wisconsin Rapids Center, Wisconsin Rapids

54501

Ministry Medical Group at Saint Mary's Hospital, Rhinelander

54548

Marshfield Clinic - Lakeland Center, Minocqua

54701

Center for Cancer Treatment & Prevention at Sacred Heart Hospital, Eau Claire

Marshfield Clinic Cancer Care at Regional Cancer Center, Eau Claire

54868

Marshfield Clinic - Indianhead Center, Rice Lake

55101

Regions Hospital Cancer Care Center, Saint Paul

55102

United Hospital, Saint Paul

55109

HealthEast Cancer Care at St. John's Hospital, Maplewood

Minnesota Oncology - Maplewood, Maplewood

55125

Minnesota Oncology - Woodbury, Woodbury

55337

Fairview Ridges Hospital, Burnsville

55350

Hutchinson Area Health Care, Hutchinson

55355

Meeker County Memorial Hospital, Litchfield

55379

St. Francis Cancer Center at St. Francis Medical Center, Shakopee

55387

Ridgeview Medical Center, Waconia

55407

Virginia Piper Cancer Institute at Abbott - Northwestern Hospital, Minneapolis

55415

Hennepin County Medical Center - Minneapolis, Minneapolis

55416

CCOP - Metro-Minnesota, Saint Louis Park

Park Nicollet Cancer Center, Saint Louis Park

55417

Veterans Affairs Medical Center - Minneapolis, Minneapolis

55432

Mercy and Unity Cancer Center at Unity Hospital, Fridley

55433

Mercy and Unity Cancer Center at Mercy Hospital, Coon Rapids

55435

Fairview Southdale Hospital, Edina

55805

CCOP - Duluth, Duluth

Miller - Dwan Medical Center, Duluth

57105

Avera Cancer Institute, Sioux Falls

Medical X-Ray Center, PC, Sioux Falls

60426

Ingalls Cancer Care Center at Ingalls Memorial Hospital, Harvey

60435

Joliet Oncology-Hematology Associates, Limited - West, Joliet

60504

Rush-Copley Cancer Care Center, Aurora

61350

Community Hospital of Ottawa, Ottawa

Oncology Hematology Associates of Central Illinois, PC - Ottawa, Ottawa

61354

Illinois Valley Community Hospital, Peru

61356

Perry Memorial Hospital, Princeton

61362

St. Margaret's Hospital, Spring Valley

61401

Galesburg Clinic, PC, Galesburg

Galesburg Cottage Hospital, Galesburg

61455

McDonough District Hospital, Macomb

61520

Graham Hospital, Canton

61530

Eureka Community Hospital, Eureka

61554

Cancer Treatment Center at Pekin Hospital, Pekin

61614

Proctor Hospital, Peoria

61615

CCOP - Illinois Oncology Research Association, Peoria

Oncology Hematology Associates of Central Illinois, PC - Peoria, Peoria

61636

Methodist Medical Center of Illinois, Peoria

61637

OSF St. Francis Medical Center, Peoria

61701

St. Joseph Medical Center, Bloomington

61747

Hopedale Medical Complex, Hopedale

61761

BroMenn Regional Medical Center, Normal

Community Cancer Center, Normal

61801

Carle Cancer Center at Carle Foundation Hospital, Urbana

CCOP - Carle Cancer Center, Urbana

62321

Memorial Hospital, Carthage

62526

Decatur Memorial Hospital Cancer Care Institute, Decatur

62644

Mason District Hospital, Havana

63131

Missouri Baptist Cancer Center, St Louis

63141

Arch Medical Services, Incorporated at Center for Cancer Care and Research, St Louis

64050

Independence Regional Health Center, Independence

64068

Liberty Hospital, Liberty

64108

Truman Medical Center - Hospital Hill, Kansas City

64111

Saint Luke's Cancer Institute at Saint Luke's Hospital, Kansas City

64114

St. Joseph Medical Center, Kansas City

64116

North Kansas City Hospital, Kansas City

Parvin Radiation Oncology, Kansas City

64131

CCOP - Kansas City, Kansas City

64132

Research Medical Center, Kansas City

64506

Heartland Regional Medical Center, Saint Joseph

66044

Lawrence Memorial Hospital, Lawrence

66204

Shawnee Mission Medical Center, Shawnee Mission

66209

Menorah Medical Center, Overland Park

66701

Cancer Center of Kansas - Fort Scott, Fort Scott

66720

Cancer Center of Kansas, PA - Chanute, Chanute

67003

Hospital District Sixth of Harper County, Anthony

67042

Cancer Center of Kansas, PA - El Dorado, El Dorado

Cancer Center of Kansas, PA - Salina, Salina

67068

Cancer Center of Kansas, PA - Kingman, Kingman

67114

Cancer Center of Kansas, PA - Newton, Newton

67124

Cancer Center of Kansas, PA - Pratt, Pratt

67152

Cancer Center of Kansas, PA - Wellington, Wellington

67156

Cancer Center of Kansas, PA - Winfield, Winfield

67208

Associates in Womens Health, PA - North Review, Wichita

Cancer Center of Kansas, PA - Medical Arts Tower, Wichita

67214

Cancer Center of Kansas, PA - Wichita, Wichita

CCOP - Wichita, Wichita

Via Christi Cancer Center at Via Christi Regional Medical Center, Wichita

67301

Cancer Center of Kansas-Independence, Independence

67357

Cancer Center of Kansas, PA - Parsons, Parsons

67801

Cancer Center of Kansas, PA - Dodge City, Dodge City

67901

Southwest Medical Center, Liberal

68106

CCOP - Missouri Valley Cancer Consortium, Omaha

68114

Methodist Estabrook Cancer Center, Omaha

68122

Immanuel Medical Center, Omaha

68124

Alegant Health Cancer Center at Bergan Mercy Medical Center, Omaha

76508

CCOP - Scott and White Hospital, Temple

89102

University Medical Center of Southern Nevada, Las Vegas

89106

CCOP - Nevada Cancer Research Foundation, Las Vegas

06856

Norwalk Hospital, Norwalk

60637-1470

University of Chicago Cancer Research Center, Chicago

60201-1781

Evanston Hospital, Evanston

61104-2315

Swedish-American Regional Cancer Center, Rockford

62781-0001

Regional Cancer Center at Memorial Medical Center, Springfield

46202-5289

Indiana University Melvin and Bren Simon Cancer Center, Indianapolis

52242-1002

Holden Comprehensive Cancer Center at University of Iowa, Iowa City

04401

CancerCare of Maine at Eastern Maine Medical Center, Bangor

02114

Massachusetts General Hospital, Boston

02115

Dana-Farber/Brigham and Women's Cancer Center, Boston

Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer Institute, Boston

01805

Lahey Clinic Medical Center - Burlington, Burlington

02190

South Shore Hospital, South Weymouth

01199

Baystate Regional Cancer Program at D'Amour Center for Cancer Care, Springfield

48106-0995

Saint Joseph Mercy Cancer Center, Ann Arbor

48123-2500

Oakwood Cancer Center at Oakwood Hospital and Medical Center, Dearborn

49007-3731

West Michigan Cancer Center, Kalamazoo

48912-1811

Sparrow Regional Cancer Center, Lansing

48341-2985

St. Joseph Mercy Oakland, Pontiac

55805-1983

Essentia Health - Duluth Clinic, Duluth

55422-2900

Humphrey Cancer Center at North Memorial Outpatient Center, Robbinsdale

68131-2197

Creighton University Medical Center, Omaha

03756-0002

Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center, Lebanon

08053

Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton, Marlton

07112

Newark Beth Israel Medical Center, Newark

07871

Frederick R. and Betty M. Smith Cancer Treatment Center, Sparta

08043

Cancer Institute of New Jersey at Cooper - Voorhees, Voorhees Township

Fox Chase Virtua Health Cancer Program at Virtua West Jersey, Voorhees Township

27599-7295

Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill, Chapel Hill

28232-2861

Blumenthal Cancer Center at Carolinas Medical Center, Charlotte

44309-2090

Summa Center for Cancer Care at Akron City Hospital, Akron

44710-1799

Aultman Cancer Center at Aultman Hospital, Canton

43210-1240

Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center, Columbus

17822-0001

Geisinger Cancer Institute at Geisinger Health, Danville

17033-0850

Penn State Hershey Cancer Institute at Milton S. Hershey Medical Center, Hershey

19104-4283

Abramson Cancer Center of the University of Pennsylvania, Philadelphia

19107-5541

Kimmel Cancer Center at Thomas Jefferson University - Philadelphia, Philadelphia

19111-2497

Fox Chase Cancer Center - Philadelphia, Philadelphia

57117-5039

Sanford Cancer Center at Sanford USD Medical Center, Sioux Falls

05602

Mountainview Medical, Berlin Corners

05401

Fletcher Allen Health Care - University Health Center Campus, Burlington

54301-3526

Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center, Green Bay

54307-3508

St. Vincent Hospital Regional Cancer Center, Green Bay

Sponsors
All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

collaborator

Eastern Cooperative Oncology Group

NETWORK

collaborator

Bristol-Myers Squibb

INDUSTRY

collaborator

Sanofi

INDUSTRY

collaborator

Pfizer

INDUSTRY

lead

Alliance for Clinical Trials in Oncology

OTHER