Low-Dose or High-Dose Vincristine and Combination Chemotherapy in Treating Young Patients With Relapsed B-Cell Acute Lymphoblastic Leukemia

PHASE3CompletedINTERVENTIONAL
Enrollment

275

Participants

Timeline

Start Date

March 31, 2007

Primary Completion Date

March 31, 2016

Conditions
B-cell Childhood Acute Lymphoblastic LeukemiaL1 Childhood Acute Lymphoblastic LeukemiaL2 Childhood Acute Lymphoblastic LeukemiaIntermediate Risk Recurrent Childhood Acute Lymphoblastic Leukemia
Interventions
DRUG

vincristine sulfate

Given IV

DRUG

prednisone

Given PO

DRUG

doxorubicin hydrochloride

Given IV

DRUG

pegaspargase

Given IM

DRUG

cytarabine

Given IT or IV

DRUG

methotrexate

Given IT or IV

DRUG

dexamethasone

Given PO

DRUG

etoposide

Given IV

DRUG

cyclophosphamide

Given IV

DRUG

leucovorin calcium

Given IV or PO

BIOLOGICAL

filgrastim

Given IV or SC

DRUG

asparaginase

Given IM

DRUG

mercaptopurine

Given PO

Trial Locations (173)

1011

Swiss Pediatric Oncology Group - Lausanne, Lausanne

3010

Swiss Pediatric Oncology Group - Bern, Bern

6008

Princess Margaret Hospital for Children, Perth

10016

New York University Langone Medical Center, New York

10029

Mount Sinai Medical Center, New York

10032

Columbia University Medical Center, New York

10595

New York Medical College, Valhalla

11040

The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park

13210

State University of New York Upstate Medical University, Syracuse

14263

Roswell Park Cancer Institute, Buffalo

15224

Children's Hospital of Pittsburgh of UPMC, Pittsburgh

17033

Penn State Hershey Children's Hospital, Hershey

18017

Lehigh Valley Hospital - Muhlenberg, Bethlehem

19104

Children's Hospital of Philadelphia, Philadelphia

19134

Saint Christopher's Hospital for Children, Philadelphia

19803

Alfred I duPont Hospital for Children, Wilmington

20010

Children's National Medical Center, Washington D.C.

20057

Lombardi Comprehensive Cancer Center at Georgetown University, Washington D.C.

21215

Sinai Hospital of Baltimore, Baltimore

22908

University of Virginia, Charlottesville

23507

Childrens Hospital-King's Daughters, Norfolk

24014

Carilion Clinic Children's Hospital, Roanoke

25304

West Virginia University Charleston, Charleston

27157

Wake Forest University Health Sciences, Winston-Salem

27599

University of North Carolina, Chapel Hill

27710

Duke University Medical Center, Durham

27858

East Carolina University, Greenville

28203

Carolinas Medical Center, Charlotte

28204

Presbyterian Hospital, Charlotte

28801

Mission Hospitals Inc, Asheville

29203

Palmetto Health Richland, Columbia

29605

BI-LO Charities Children's Cancer Center, Greenville

Greenville Cancer Treatment Center, Greenville

30322

Children's Healthcare of Atlanta - Egleston, Atlanta

30912

Georgia Regents University, Augusta

31403

Memorial Health University Medical Center, Savannah

32504

Nemours Children's Clinic - Pensacola, Pensacola

32610

University of Florida, Gainesville

32803

Florida Hospital, Orlando

32806

M D Anderson Cancer Center- Orlando, Orlando

Nemours Childrens Clinic - Orlando, Orlando

33136

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33155

Miami Children's Hospital, Miami

33176

Baptist Hospital of Miami, Miami

33316

Broward Health Medical Center, Fort Lauderdale

33407

Saint Mary's Hospital, West Palm Beach

33607

Saint Joseph Children's Hospital of Tampa, Tampa

33701

All Children's Hospital, St. Petersburg

33901

Lee Memorial Health System, Fort Myers

35233

Children's Hospital of Alabama, Birmingham

35294

University of Alabama at Birmingham, Birmingham

37232

Vanderbilt-Ingram Cancer Center, Nashville

37403

T C Thompson Children's Hospital, Chattanooga

37916

East Tennessee Childrens Hospital, Knoxville

39216

University of Mississippi Medical Center, Jackson

40202

Kosair Children's Hospital, Louisville

40536

University of Kentucky, Lexington

43205

Nationwide Children's Hospital, Columbus

43608

Mercy Children's Hospital, Toledo

44106

Rainbow Babies and Childrens Hospital, Cleveland

44195

Cleveland Clinic Foundation, Cleveland

44308

Children's Hospital Medical Center of Akron, Akron

45229

Cincinnati Children's Hospital Medical Center, Cincinnati

45404

The Children's Medical Center of Dayton, Dayton

46202

Riley Hospital for Children, Indianapolis

46260

Saint Vincent Hospital and Health Services, Indianapolis

48109

C S Mott Children's Hospital, Ann Arbor

48202

Wayne State University, Detroit

48502

Hurley Medical Center, Flint

48910

Michigan State University - Breslin Cancer Center, Lansing

49007

Bronson Methodist Hospital, Kalamazoo

49008

Kalamazoo Center for Medical Studies, Kalamazoo

49503

Helen DeVos Children's Hospital at Spectrum Health, Grand Rapids

50309

Raymond Blank Children's Hospital, Des Moines

53226

Midwest Children's Cancer Center, Milwaukee

53792

University of Wisconsin Hospital and Clinics, Madison

54301

Saint Vincent Hospital, Green Bay

54449

Marshfield Clinic, Marshfield

55404

Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis

55455

University of Minnesota Medical Center-Fairview, Minneapolis

55905

Mayo Clinic, Rochester

60068

Advocate Lutheran General Hospital, Park Ridge

60153

Loyola University Medical Center, Maywood

60453

Advocate Hope Children's Hospital, Oak Lawn

60612

University of Illinois, Chicago

60614

Childrens Memorial Hospital, Chicago

62702

Southern Illinois University, Springfield

63141

Saint John's Mercy Medical Center, St Louis

64108

The Childrens Mercy Hospital, Kansas City

65212

University of Missouri-Columbia, Columbia

68114

Children's Hospital and Medical Center of Omaha, Omaha

68198

University of Nebraska Medical Center, Omaha

70112

Tulane University Health Sciences Center, New Orleans

70118

Children's Hospital-Main Campus, New Orleans

70121

Ochsner Clinic Foundation, New Orleans

72205

University of Arkansas for Medical Sciences, Little Rock

73104

University of Oklahoma Health Sciences Center, Oklahoma City

75230

Medical City Dallas Hospital, Dallas

75390

University of Texas Southwestern Medical Center, Dallas

76104

Cook Children's Medical Center, Fort Worth

76508

Scott and White Memorial Hospital, Temple

77030

Baylor College of Medicine, Houston

78229

Methodist Children's Hospital of South Texas, San Antonio

78234

Brooke Army Medical Center, Fort Sam Houston

78411

Driscoll Children's Hospital, Corpus Christi

78723

Dell Children's Medical Center of Central Texas, Austin

79106

Texas Tech University Health Science Center-Amarillo, Amarillo

79410

Covenant Children's Hospital, Lubbock

80045

Children's Hospital Colorado, Aurora

80218

Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center, Denver

83712

Saint Luke's Mountain States Tumor Institute, Boise

84113

Primary Children's Medical Center, Salt Lake City

85016

Phoenix Childrens Hospital, Phoenix

85724

University of Arizona Health Sciences Center, Tucson

87106

University of New Mexico Cancer Center, Albuquerque

89106

Nevada Cancer Research Foundation CCOP, Las Vegas

90027

Children's Hospital Los Angeles, Los Angeles

90048

Cedars-Sinai Medical Center, Los Angeles

90242

Southern California Permanente Medical Group, Downey

90806

Miller Children's Hospital, Long Beach

91010

City of Hope Medical Center, Duarte

92123

Rady Children's Hospital - San Diego, San Diego

92354

Loma Linda University Medical Center, Loma Linda

93102

Santa Barbara Cottage Hospital, Santa Barbara

94143

University of California San Francisco Medical Center-Parnassus, San Francisco

94304

Lucile Packard Children's Hospital Stanford University, Palo Alto

94611

Kaiser Permanente-Oakland, Oakland

95816

Sutter General Hospital, Sacramento

95817

UC Davis Comprehensive Cancer Center, Sacramento

96813

University of Hawaii, Honolulu

97227

Legacy Emanuel Children's Hospital, Portland

Legacy Emanuel Hospital and Health Center, Portland

97239

Oregon Health and Science University, Portland

98405

Mary Bridge Children's Hospital and Health Center, Tacoma

98431

Madigan Army Medical Center, Tacoma

99204

Providence Sacred Heart Medical Center and Children's Hospital, Spokane

91006-3776

Children's Oncology Group, Arcadia

93636-8762

Children's Hospital Central California, Madera

94609-1809

Children's Hospital and Research Center at Oakland, Oakland

92868-3874

Childrens Hospital of Orange County, Orange

06106

Connecticut Children's Medical Center, Hartford

06520-8032

Yale University, New Haven

32207-8426

Nemours Children's Clinic - Jacksonville, Jacksonville

04401

Eastern Maine Medical Center, Bangor

04074

Maine Children's Cancer Program, Scarborough

21201-1595

University of Maryland Greenebaum Cancer Center, Baltimore

21287-8936

Johns Hopkins University, Baltimore

20889-5600

Walter Reed National Military Medical Center, Bethesda

01655

University of Massachusetts Medical School, Worcester

03756

Dartmouth Hitchcock Medical Center, Lebanon

07601

Hackensack University Medical Center, Hackensack

07039

Saint Barnabas Medical Center, Livingston

07962

Morristown Memorial Hospital, Morristown

08901

Saint Peter's University Hospital, New Brunswick

08903

UMDNJ - Robert Wood Johnson University Hospital, New Brunswick

07112

Newark Beth Israel Medical Center, Newark

07503

Saint Joseph's Regional Medical Center, Paterson

07902

Overlook Hospital, Summit

10467-2490

Montefiore Medical Center, The Bronx

02903

Rhode Island Hospital, Providence

57117-5134

Sanford USD Medical Center - Sioux Falls, Sioux Falls

78229-3900

University of Texas Health Science Center at San Antonio, San Antonio

V6H 3V4

British Columbia Children's Hospital, Vancouver

R3E 0V9

CancerCare Manitoba, Winnipeg

B3J 3G9

IWK Health Centre, Halifax

L8N 3Z5

McMaster Children's Hospital at Hamilton Health Sciences, Hamilton

L8S 4L8

Chedoke-McMaster Hospitals, Hamilton

K7L 5P9

Cancer Centre of Southeastern Ontario at Kingston General Hospital, Kingston

N6A 5W9

Children's Hospital, London

K1H 8L1

Children's Hospital of Eastern Ontario, Ottawa

H3T 1C5

Hospital Sainte-Justine, Montreal

S4T 7T1

Allan Blair Cancer Centre, Regina

S7N 4H4

Saskatoon Cancer Centre, Saskatoon

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Children's Oncology Group

NETWORK

NCT00381680 - Low-Dose or High-Dose Vincristine and Combination Chemotherapy in Treating Young Patients With Relapsed B-Cell Acute Lymphoblastic Leukemia | Biotech Hunter | Biotech Hunter