S0601 Rituximab, Combination Chemotherapy, and Bortezomib Followed by Bortezomib Alone in Treating Patients With Newly Diagnosed Mantle Cell Lymphoma

PHASE2CompletedINTERVENTIONAL
Enrollment

68

Participants

Timeline

Start Date

August 31, 2006

Primary Completion Date

December 31, 2012

Study Completion Date

September 30, 2017

Conditions
Lymphoma
Interventions
BIOLOGICAL

rituximab

375 mg/m\^2 on day 1 for cycles 1-6.

DRUG

bortezomib

1.3 mg/m\^2 on days 1, 4 of cycles 1-6 and on days 1, 4, 8, 11 of cycles 7-14.

DRUG

cyclophosphamide

750 mg/m\^2 on day 1 of cycles 1-6.

DRUG

doxorubicin hydrochloride

50 mg/m\^2 on day 1 of cycles 1-6.

DRUG

prednisone

100 mg on days 1-5 of cycles 1-6.

DRUG

vincristine sulfate

1.4 mg/m\^2 on day 1 of cycles 1-6.

Trial Locations (147)

12801

Adirondack Cancer Care - Glens Falls, Glens Falls

14623

Interlakes Oncology/Hematology PC, Rochester

14642

James P. Wilmot Cancer Center at University of Rochester Medical Center, Rochester

24273

Southwest Virginia Regional Cancer Center at Wellmonth Health, Norton

24541

Danville Regional Medical Center, Danville

27534

Wayne Memorial Hospital, Incorporated, Goldsboro

28139

Rutherford Hospital, Rutherfordton

28791

Pardee Memorial Hospital, Hendersonville

29303

CCOP - Upstate Carolina, Spartanburg

Gibbs Regional Cancer Center at Spartanburg Regional Medical Center, Spartanburg

29425

Hollings Cancer Center at Medical University of South Carolina, Charleston

29621

AnMed Cancer Center, Anderson

32806

M.D. Anderson Cancer Center at Orlando, Orlando

33316

Broward General Medical Center Cancer Center, Fort Lauderdale

37662

Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center, Kingsport

39216

University of Mississippi Cancer Clinic, Jackson

43015

Grady Memorial Hospital, Delaware

43055

Licking Memorial Cancer Care Program at Licking Memorial Hospital, Newark

43081

Mount Carmel St. Ann's Cancer Center, Westerville

43130

Fairfield Medical Center, Lancaster

43215

CCOP - Columbus, Columbus

Grant Medical Center Cancer Care, Columbus

43222

Mount Carmel Health - West Hospital, Columbus

43228

Doctors Hospital at Ohio Health, Columbus

43311

Mary Rutan Hospital, Bellefontaine

43701

Genesis - Good Samaritan Hospital, Zanesville

45267

Charles M. Barrett Cancer Center at University Hospital, Cincinnati

45385

Ruth G. McMillan Cancer Center at Greene Memorial Hospital, Xenia

45405

Grandview Hospital, Dayton

45406

Good Samaritan Hospital, Dayton

45409

David L. Rike Cancer Center at Miami Valley Hospital, Dayton

45415

Samaritan North Cancer Care Center, Dayton

45428

Veterans Affairs Medical Center - Dayton, Dayton

45429

CCOP - Dayton, Dayton

Charles F. Kettering Memorial Hospital, Kettering

45504

Mercy Medical Center, Springfield

45505

Community Hospital of Springfield and Clark County, Springfield

45601

Adena Regional Medical Center, Chillicothe

45750

Strecker Cancer Center at Marietta Memorial Hospital, Marietta

45840

Blanchard Valley Medical Associates, Findlay

46107

St. Francis Hospital and Health Centers - Beech Grove Campus, Beech Grove

47374

Reid Hospital & Health Care Services, Richmond

48910

Breslin Cancer Center at Ingham Regional Medical Center, Lansing

49017

Battle Creek Health System Cancer Care Center, Battle Creek

49307

Mecosta County Medical Center, Big Rapids

49423

Holland Community Hospital, Holland

49442

Hackley Hospital, Muskegon

49503

Butterworth Hospital at Spectrum Health, Grand Rapids

CCOP - Grand Rapids, Grand Rapids

Lacks Cancer Center at Saint Mary's Health Care, Grand Rapids

49506

Metro Health Hospital, Grand Rapids

49684

Munson Medical Center, Traverse City

59101

CCOP - Montana Cancer Consortium, Billings

Hematology-Oncology Centers of the Northern Rockies - Billings, Billings

Northern Rockies Radiation Oncology Center, Billings

St. Vincent Healthcare Cancer Care Services, Billings

59405

Great Falls Clinic - Main Facility, Great Falls

Sletten Cancer Institute at Benefis Healthcare, Great Falls

Great Falls

59601

St. Peter's Hospital, Helena

59701

St. James Healthcare Cancer Care, Butte

59715

Bozeman Deaconess Cancer Center, Bozeman

59801

Community Medical Center, Missoula

59804

Guardian Oncology and Center for Wellness, Missoula

59807

Montana Cancer Center at St. Patrick Hospital and Health Sciences Center, Missoula

59901

Glacier Oncology, PLLC, Kalispell

Kalispell Medical Oncology at KRMC, Kalispell

Kalispell Regional Medical Center, Kalispell

62526

Decatur Memorial Hospital Cancer Care Institute, Decatur

64131

CCOP - Kansas City, Kansas City

65802

CCOP - Cancer Research for the Ozarks, Springfield

65804

St. John's Regional Health Center, Springfield

65807

Hulston Cancer Center at Cox Medical Center South, Springfield

66061

Olathe Cancer Center, Olathe

66606

Cotton-O'Neil Cancer Center, Topeka

St. Francis Comprehensive Cancer Center, Topeka

66720

Cancer Center of Kansas, PA - Chanute, Chanute

67042

Cancer Center of Kansas, PA - El Dorado, El Dorado

Cancer Center of Kansas, PA - Salina, Salina

67068

Cancer Center of Kansas, PA - Kingman, Kingman

67114

Cancer Center of Kansas, PA - Newton, Newton

67124

Cancer Center of Kansas, PA - Pratt, Pratt

67152

Cancer Center of Kansas, PA - Wellington, Wellington

67156

Cancer Center of Kansas, PA - Winfield, Winfield

67203

Associates in Womens Health, PA - North Review, Wichita

67208

Cancer Center of Kansas, PA - Medical Arts Tower, Wichita

67214

Cancer Center of Kansas, PA - Wichita, Wichita

CCOP - Wichita, Wichita

Via Christi Cancer Center at Via Christi Regional Medical Center, Wichita

67357

Cancer Center of Kansas, PA - Parsons, Parsons

67401

Tammy Walker Cancer Center at Salina Regional Health Center, Salina

67801

Cancer Center of Kansas, PA - Dodge City, Dodge City

67901

Southwest Medical Center, Liberal

72205

Arkansas Cancer Research Center at University of Arkansas for Medical Sciences, Little Rock

76508

CCOP - Scott and White Hospital, Temple

80524

Poudre Valley Hospital, Fort Collins

82801

Welch Cancer Center at Sheridan Memorial Hospital, Sheridan

83712

Mountain States Tumor Institute at St. Luke's Regional Medical Center, Boise

84003

American Fork Hospital, American Fork

84103

LDS Hospital, Salt Lake City

84106

Utah Cancer Specialists at UCS Cancer Center, Salt Lake City

84107

Cottonwood Hospital Medical Center, Murray

84157

Jon and Karen Huntsman Cancer Center at Intermountain Medical Center, Murray

84321

Logan Regional Hospital, Logan

84403

Val and Ann Browning Cancer Center at McKay-Dee Hospital Center, Ogden

84604

Utah Valley Regional Medical Center - Provo, Provo

84720

Sandra L. Maxwell Cancer Center, Cedar City

84770

Dixie Regional Medical Center - East Campus, St. George

91505

Providence Saint Joseph Medical Center - Burbank, Burbank

94533

North Bay Cancer Center, Fairfield

97030

Legacy Mount Hood Medical Center, Gresham

97062

Legacy Meridian Park Hospital, Tualatin

97210

Legacy Good Samaritan Hospital & Comprehensive Cancer Center, Portland

97216

Adventist Medical Center, Portland

97222

Providence Milwaukie Hospital, Milwaukie

97225

CCOP - Columbia River Oncology Program, Portland

Providence St. Vincent Medical Center, Portland

97227

Legacy Emanuel Hospital and Health Center and Children's Hospital, Portland

98104

Fred Hutchinson Cancer Research Center, Seattle

Harborview Medical Center, Seattle

Minor and James Medical, PLLC, Seattle

98112

Group Health Central Hospital, Seattle

98122

Polyclinic First Hill, Seattle

98225

St. Joseph Cancer Center, Bellingham

98310

Olympic Hematology and Oncology, Bremerton

98668

Southwest Washington Medical Center Cancer Center, Vancouver

99202

Cancer Care Northwest - Spokane South, Spokane

99336

Columbia Basin Hematology, Kennewick

99508

Alaska Regional Hospital Cancer Center, Anchorage

Providence Cancer Center, Anchorage

85724-5024

Arizona Cancer Center at University of Arizona Health Sciences Center, Tucson

66160-7357

Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center, Kansas City

02118

Boston University Cancer Research Center, Boston

48109-0942

University of Michigan Comprehensive Cancer Center, Ann Arbor

59107-7000

Billings Clinic - Downtown, Billings

59405-5309

Big Sky Oncology, Great Falls

59807-7877

Montana Cancer Specialists at Montana Cancer Center, Missoula

68848-1990

Good Samaritan Cancer Center at Good Samaritan Hospital, Kearney

10940-4199

Tucker Center for Cancer Care at Orange Regional Medical Center, Middletown

28232-2861

Blumenthal Cancer Center at Carolinas Medical Center, Charlotte

43214-3998

Riverside Methodist Hospital Cancer Care, Columbus

45005-1066

Middletown Regional Hospital, Franklin

45373-1300

UVMC Cancer Care Center at Upper Valley Medical Center, Troy

97213-2967

Providence Cancer Center at Providence Portland Medical Center, Portland

98122-4307

Swedish Cancer Institute at Swedish Medical Center - First Hill Campus, Seattle

98195-6043

University Cancer Center at University of Washington Medical Center, Seattle

98801-2028

Wenatchee Valley Medical Center, Wenatchee

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

SWOG Cancer Research Network

NETWORK

NCT00376961 - S0601 Rituximab, Combination Chemotherapy, and Bortezomib Followed by Bortezomib Alone in Treating Patients With Newly Diagnosed Mantle Cell Lymphoma | Biotech Hunter | Biotech Hunter