Cetuximab in Treating Patients With Advanced Solid Tumors

PHASE1CompletedINTERVENTIONAL
Enrollment

27

Participants

Timeline

Start Date

December 31, 2004

Primary Completion Date

November 30, 2007

Study Completion Date

December 31, 2007

Conditions
Unspecified Adult Solid Tumor, Protocol Specific
Interventions
BIOLOGICAL

cetuximab

Dose level 0: cetuximab 400 mg/m2 week 1, 250 mg/m2 weekly; Dose level 1: cetuximab 400 mg/m2 week 1, 300 mg/m2 weekly; Dose level 2: cetuximab 400 mg/m2 week 1, 350 mg/m2 weekly; Dose level 3: cetuximab 400 mg/m2 week 1, 400 mg/m2 weekly

GENETIC

molecular diagnostic method

Tissue and Blood Specimens; IHC Methodology; IHC Scoring; K-RAS Mutation Analysis

OTHER

immunologic technique

Peripheral Blood Mononuclear Cells (PBMC)

OTHER

laboratory biomarker analysis

Cetuximab Pharmacodynamics

Trial Locations (1)

95817

University of California Davis Cancer Center, Sacramento

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

University of California, Davis

OTHER

NCT00376727 - Cetuximab in Treating Patients With Advanced Solid Tumors | Biotech Hunter | Biotech Hunter