Intra-arterial Stem Cell Therapy for Patients With Chronic Limb Ischemia (CLI)

A total volume of 100 ml bone marrow will be aspirated from the iliac crest under local anaesthesia (lidocaine) according to local routine. To maximise the patients comfort, 5-10 mg midazolam and 50 ug fentanyl will be administered intravenously.

Repeated intra-arterial infusion of autologous BM-MNC into the common femoral artery

Repeated intra-arterial infusion of placebo (PBS/4% HAS/heparin, coloured with autologous erythrocytes to match the colour of BM-MNC suspension) into the common femoral artery.