External Beam Radiation With Intratumoral Injection of Dendritic Cells As Neo-Adjuvant Treatment for Sarcoma

PHASE2CompletedINTERVENTIONAL
Enrollment

17

Participants

Timeline

Start Date

May 31, 2006

Primary Completion Date

June 30, 2012

Study Completion Date

June 30, 2012

Conditions
Soft Tissue Sarcoma
Interventions
BIOLOGICAL

Dendritic Cell (DC) Injections

"* DCs (10\^7 cells) were injected intratumorally three times on the second, third, and fourth Friday during the course of radiation.~* One additional DC injection was given before surgery to assess DC migration~* Patients were assigned to one of three cohorts:~Group 1 - DC injection # 4 given 24 hours prior to surgery Group 2 - DC injection # 4 given 48 hours prior to surgery Group 3 - DC injection # 4 given 72 hours prior to surgery"

PROCEDURE

Radiation therapy

Radiation was delivered 5 days per week (Monday-Friday).

PROCEDURE

Complete Resection - Surgery for tumor removal

Tumors were surgically resected 3-6 weeks after the completion of EBRT.

Trial Locations (1)

33612

H. Lee Moffitt Cancer Center & Research Institute, Tampa

Sponsors
All Listed Sponsors
collaborator

Cancer Treatment Research Foundation

OTHER

lead

H. Lee Moffitt Cancer Center and Research Institute

OTHER