Zoledronate, Vitamin D, and Calcium With or Without Strontium 89 or Samarium 153 in Preventing or Delaying Bone Problems in Patients With Bone Metastases From Prostate Cancer, Lung Cancer, or Breast Cancer

PHASE3CompletedINTERVENTIONAL
Enrollment

261

Participants

Timeline

Start Date

July 11, 2006

Primary Completion Date

January 31, 2012

Study Completion Date

February 27, 2017

Conditions
Breast CancerLung CancerMetastatic CancerPainProstate Cancer
Interventions
DIETARY_SUPPLEMENT

Calcium

At least 500 mg of calcium (1 pill) by mouth daily until the study doctor thinks it is in their best interest to stop.

DIETARY_SUPPLEMENT

Vitamin D

400 IU of vitamin D (1 pill) by mouth daily until the study doctor thinks it is in their best interest to stop.

DRUG

zoledronic acid

4 mg of Zoledronic acid intravenously once a month until the study doctor thinks it is in their best interest to stop.

DRUG

Sm-153

Single dose intravenously 1 mCi/kg body weight.

RADIATION

Sr-89

Single dose intravenously 4 mCi.

Trial Locations (147)

11215

New York Methodist Hospital, Brooklyn

12901

Fitzpatrick Cancer Center at Champlain Valley Physicians Hospital Medical Center, Plattsburgh

14424

Sands Cancer Center, Canandaigua

14620

Highland Hospital of Rochester, Rochester

14621

Lipson Cancer and Blood Center at Rochester General Hospital, Rochester

14626

University Radiation Oncology at Parkridge Hospital, Rochester

14642

James P. Wilmot Cancer Center at University of Rochester Medical Center, Rochester

15009

UPMC Cancer Center at Beaver Medical Center, Beaver

15025

UPMC Cancer Center at Jefferson Regional Medical Center, Clairton

15065

UPMC Cancer Center - Natrona Heights, Natrona Heights

15108

UPMC - Moon, Moon Township

15132

UPMC Cancer Center at UPMC McKeesport, McKeesport

15213

UPMC Cancer Center at Magee-Womens Hospital, Pittsburgh

UPMC Cancer Center at UPMC Presbyterian, Pittsburgh

15215

UPMC Cancer Center at UPMC St. Margaret, Pittsburgh

15237

UPMC Cancer Center at UPMC Passavant, Pittsburgh

15243

UPMC Cancer Center - Upper St. Clair, Pittsburgh

15301

Washington Hospital Cancer Center, Washington

15401

UPMC Cancer Center - Uniontown, Uniontown

15601

UPMC Cancer Center - Arnold Palmer Pavilion, Greensburg

15901

UPMC Cancer Center at the John P. Murtha Pavilion, Johnstown

16105

Jameson Memorial Hospital - North Campus, New Castle

16346

UPMC Cancer Center at UPMC Northwest, Seneca

16803

Mount Nittany Medical Center, State College

17405

York Cancer Center at Apple Hill Medical Center, York

18512

Northeast Radiation Oncology Center, Dunmore

19001

Rosenfeld Cancer Center at Abington Memorial Hospital, Abington

21229

St. Agnes Hospital Cancer Center, Baltimore

27534

Wayne Radiation Oncology, Goldsboro

28801

Mission Hospitals - Memorial Campus, Asheville

29425

Hollings Cancer Center at Medical University of South Carolina, Charleston

29615

CCOP - Greenville, Greenville

30501

Northeast Georgia Medical Center, Gainesville

31904

John B. Amos Cancer Center, Columbus

32073

Integrated Community Oncology Network - Orange Park, Orange Park

32086

Flagler Cancer Center, Saint Augustine

32177

Florida Cancer Center - Palatka, Palatka

32207

Baptist Cancer Institute - Jacksonville, Jacksonville

Integrated Community Oncology Network at Southside Cancer Center, Jacksonville

32250

Integrated Community Oncology Network, Jacksonville Beach

32258

Baptist Medical Center South, Jacksonville

32401

Bay Medical, Panama City

33133

Miami Cancer Center at Mercy Hospital, Miami

33140

CCOP - Mount Sinai Medical Center, Miami Beach

33308

Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital, Fort Lauderdale

36608

Providence Cancer Center at Providence Hospital, Mobile

39581

Regional Cancer Center at Singing River Hospital, Pascagoula

43215

CCOP - Columbus, Columbus

44203

Barberton Citizens Hospital, Barberton

44307

McDowell Cancer Center at Akron General Medical Center, Akron

44460

Cancer Care Center, Incorporated, Salem

44601

Radiation Oncology Center, Alliance

44691

Cancer Treatment Center, Wooster

44708

Mercy Cancer Center at Mercy Medical Center, Canton

44903

MedCentral - Mansfield Hospital, Mansfield

45385

Ruth G. McMillan Cancer Center at Greene Memorial Hospital, Xenia

45405

Grandview Hospital, Dayton

45406

Good Samaritan Hospital, Dayton

45409

David L. Rike Cancer Center at Miami Valley Hospital, Dayton

45415

Samaritan North Cancer Care Center, Dayton

45420

CCOP - Dayton, Dayton

45429

Charles F. Kettering Memorial Hospital, Kettering

45601

Adena Regional Medical Center, Chillicothe

46526

Center for Cancer Care at Goshen General Hospital, Goshen

46601

CCOP - Northern Indiana CR Consortium, South Bend

48093

St. John Macomb Hospital, Warren

48202

Josephine Ford Cancer Center at Henry Ford Hospital, Detroit

48236

Van Elslander Cancer Center at St. John Hospital and Medical Center, Grosse Pointe Woods

48503

Genesys Hurley Cancer Institute, Flint

Hurley Medical Center, Flint

49007

Bronson Methodist Hospital, Kalamazoo

49801

Dickinson County Healthcare System, Iron Mountain

50010

McFarland Clinic, PC, Ames

50309

CCOP - Iowa Oncology Research Association, Des Moines

John Stoddard Cancer Center at Iowa Methodist Medical Center, Des Moines

Medical Oncology and Hematology Associates at John Stoddard Cancer Center, Des Moines

50314

Medical Oncology and Hematology Associates at Mercy Cancer Center, Des Moines

Mercy Cancer Center at Mercy Medical Center - Des Moines, Des Moines

51101

Siouxland Hematology-Oncology Associates, LLP, Sioux City

54301

Bellin Memorial Hospital, Green Bay

54494

Riverview UW Cancer Center at Riverview Hospital, Wisconsin Rapids

54911

Theda Care Cancer Institute, Appleton

56303

CentraCare Clinic - River Campus, Saint Cloud

58701

Trinity CancerCare Center, Minot

59101

CCOP - Montana Cancer Consortium, Billings

Northern Rockies Radiation Oncology Center, Billings

59405

Great Falls Clinic - Main Facility, Great Falls

60005

Northwest Community Hospital, Arlington Heights

60141

Veterans Affairs Medical Center - Hines, Hines

60426

Ingalls Cancer Care Center at Ingalls Memorial Hospital, Harvey

61615

Oncology Hematology Associates of Central Illinois, PC - Peoria, Peoria

61801

CCOP - Carle Cancer Center, Urbana

62702

Cancer Institute at St. John's Hospital, Springfield

64108

Truman Medical Center - Hospital Hill, Kansas City

64131

CCOP - Kansas City, Kansas City

65804

St. John's Regional Health Center, Springfield

65807

Hulston Cancer Center at Cox Medical Center South, Springfield

66044

Lawrence Memorial Hospital, Lawrence

67214

CCOP - Wichita, Wichita

74136

Natalie Warren Bryant Cancer Center at St. Francis Hospital, Tulsa

82801

Welch Cancer Center at Sheridan Memorial Hospital, Sheridan

84106

Utah Cancer Specialists at UCS Cancer Center, Salt Lake City

84143

LDS Hospital, Salt Lake City

84157

Jon and Karen Huntsman Cancer Center at Intermountain Medical Center, Murray

84770

Dixie Regional Medical Center - East Campus, St. George

87109

New Mexico Cancer Center, Albuquerque

91505

Roy and Patricia Disney Family Cancer Center at Providence Saint Joseph Medical Center, Burbank

91767

Robert and Beverly Lewis Family Cancer Care Center at Pomona Valley Hospital Medical Center, Pomona

95608

Mercy Cancer Center at Mercy San Juan Medical Center, Carmichael

95661

Radiation Oncology Center - Roseville, Roseville

95815

Radiological Associates of Sacramento Medical Group, Incorporated, Sacramento

98003

St. Francis Hospital, Federal Way

98101

CCOP - Virginia Mason Research Center, Seattle

98372

Good Samaritan Cancer Center, Puyallup

98405

CCOP - Northwest, Tacoma

MultiCare Regional Cancer Center at Tacoma General Hospital, Tacoma

98902

North Star Lodge Cancer Center at Yakima Valley Memorial Hospital, Yakima

90089-9181

USC/Norris Comprehensive Cancer Center and Hospital, Los Angeles

94535-1800

General Robert Huyser Cancer Center at David Grant Medical Center, Travis Air Force Base

33612-9497

H. Lee Moffitt Cancer Center and Research Institute at University of South Florida, Tampa

60515-1500

Good Samaritan Cancer Care Center at Advocate Good Samaritan Hospital, Downers Grove

60453-2699

Advocate Christ Medical Center, Oak Lawn

60068-1174

Advocate Lutheran General Cancer Care Center, Park Ridge

47303-3499

Cancer Center at Ball Memorial Hospital, Muncie

40503-9985

Central Baptist Hospital, Lexington

71315-3198

Tulane Cancer Center Office of Clinical Research, Alexandria

04240

Central Maine Comprehensive Cancer Center at Central Maine Medical Center, Lewiston

02721

Hudner Oncology Center at Saint Anne's Hospital - Fall River, Fall River

02601

Cape Cod Hospital, Hyannis

48106-0995

Saint Joseph Mercy Cancer Center, Ann Arbor

48123-2500

Oakwood Cancer Center at Oakwood Hospital and Medical Center, Dearborn

49007-3731

West Michigan Cancer Center, Kalamazoo

48912-1811

Sparrow Regional Cancer Center, Lansing

59107-7000

Billings Clinic - Downtown, Billings

68848-1990

Good Samaritan Cancer Center at Good Samaritan Hospital, Kearney

08831

Princeton Radiation Oncology Center, Jamesburg

08053

Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton, Marlton

08540-3298

University Medical Center at Princeton, Princeton

08360

Franklin & Edith Scarpa Regional Cancer Center at South Jersey Healthcare, Vineland

08043

Cancer Institute of New Jersey at Cooper - Voorhees, Voorhees Township

28233-3549

Presbyterian Cancer Center at Presbyterian Hospital, Charlotte

44309-2090

Summa Center for Cancer Care at Akron City Hospital, Akron

45005-1066

Middletown Regional Hospital, Franklin

45373-1300

UVMC Cancer Care Center at Upper Valley Medical Center, Troy

45433-5529

United States Air Force Medical Center - Wright-Patterson, Wright-Patterson Air Force Base

15213-2582

UPMC - Shadyside, Pittsburgh

98405-3004

Franciscan Cancer Center at St. Joseph Medical Center, Tacoma

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

collaborator

NRG Oncology

OTHER

lead

Radiation Therapy Oncology Group

NETWORK