Bevacizumab and Radiation Therapy for Sarcomas

Bevacizumab 5mg/kg given intravenously every 2 weeks for a total of 4 doses

External beam radiation given two weeks after the first bevacizumab infusion and delivered 5 days a week at 1.8 Gy per day, over 6 weeks. Total radiation dose is 50.4 Gy. For patients with tumors in the retroperitoneum or pelvis, intraoperative radiation therapy (10-20 Gy) may be given for close or positive margins at the discretion of the radiation oncologist and surgeon. For patients with tumors in the extremity or trunk, post-operative external beam radiation therapy (10-20 Gy) will be given for close or positive margins assuming wound healing is good.

Surgical resection is performed 6-7 weeks after completion of neoadjuvant therapy.