109
Participants
Start Date
July 31, 2006
Primary Completion Date
January 31, 2010
Study Completion Date
June 30, 2019
dactinomycin
"Age based dosage: ≥ 1 year 0.045 mg/kg IV x 1(maximum dose 2.5 mg), \< 1 year 0.025 mg/kg.~Day 1 of Weeks 35, 38, 41 and 44.~Given IV"
cyclophosphamide
"Age based dosage: ≥ 3 years 1200 mg/m2, \<3 years 40 mg/kg.~Day 1 of weeks 7, 11, 15, 28, 32, 35, 38, 41 and 44.~Given IV"
doxorubicin hydrochloride
"Age based dosage: ≥ 1 year: 37.5mg/m²/day, \< 1 year: treat with 50% doses calculated on a m2 basis. Total dose 75 mg/m².~Days 1 and 2 of weeks 7, 11, 15, 28 and 32.~Given IV"
etoposide
"Age based dosage: ≥ 1 year: 100 mg/m²/day, \< 1 year: treat with 50% doses calculated on a m2 basis.~Days 1-5 of weeks 9, 13, 17, 26 and 30.~Given IV"
ifosfamide
"Age based dosage: ≥ 1 year: 1800 mg/m²/day, \< 1 year: treat with 50% doses calculated on a m2 basis.~Days 1-5 of weeks 9, 13, 17, 26 and 30.~Given IV"
irinotecan hydrochloride
"Dosage 50 mg/m2-max dose 100 mg/day.~Days 1-5 of weeks 1, 4, 20, 23, 47 and 50.~Given IV"
vincristine sulfate
"Age based dosage: ≥ 3 years 1.5 mg/m2 (max dose 2 mg), ≥ 1 year and \< 3 years 0.05 mg/kg (max dose 2 mg), \< 1 year 0.025 mg/kg.~Days 1-5 of weeks 1, 2, 3, 4, 5, 7, 8, 11, 12, 15, 16, 20, 21, 22, 23, 24, 28, 29, 32, 33, 35, 38, 41, 42, 43, 44, 47, 48, 50, and 51.~Given IV"
conventional surgery
"Resection of the primary tumor with a surrounding envelope of normal tissue"
radiation therapy
Radiotherapy beginning at Week 20 to the primary tumor and to the metastatic sites excepting those with parameningeal tumors with intracranial extension (direct extension into the brain) and those requiring emergency radiotherapy
filgrastim
"5 micrograms/kg/day (max 300 micrograms) beginning 24-36 hours after the last dose of chemotherapy. Continue at least 7 days, or until the ANC ≥750/μL whichever comes last.~Given subcutaneously."
Westmead Institute for Cancer Research at Westmead Hospital, Westmead
John Hunter Hospital, Newcastle
Swiss Pediatric Oncology Group Bern, Bern
Royal Children's Hospital, Parkville
Royal Children's Hospital, Herston, Brisbane
Women's and Children's Hospital, North Adelaide
Princess Margaret Hospital for Children, Perth
NYU Cancer Institute at New York University Medical Center, New York
Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center, New York
New York Medical College, Valhalla
Schneider Children's Hospital, New Hyde Park
SUNY Upstate Medical University Hospital, Syracuse
James P. Wilmot Cancer Center at University of Rochester Medical Center, Rochester
Children's Hospital of Pittsburgh, Pittsburgh
Lehigh Valley Hospital - Muhlenberg, Bethlehem
Alfred I. duPont Hospital for Children, Wilmington
Lombardi Comprehensive Cancer Center at Georgetown University Medical Center, Washington D.C.
Alvin and Lois Lapidus Cancer Institute at Sinai Hospital, Baltimore
Carilion Medical Center for Children at Roanoke Community Hospital, Roanoke
West Virginia University Health Sciences Center - Charleston, Charleston
Duke Comprehensive Cancer Center, Durham
Mission Hospitals - Memorial Campus, Asheville
Palmetto Health South Carolina Cancer Center, Columbia
Hollings Cancer Center at Medical University of South Carolina, Charleston
Greenville Hospital Cancer Center, Greenville
Winship Cancer Institute of Emory University, Atlanta
Nemours Children's Clinic, Jacksonville
Sacred Heart Cancer Center at Sacred Heart Hospital, Pensacola
M.D. Anderson Cancer Center at Orlando, Orlando
Nemours Children's Clinic - Orlando, Orlando
Memorial Cancer Institute at Memorial Regional Hospital, Hollywood
Miami Children's Hospital, Miami
Baptist-South Miami Regional Cancer Program, Miami
Broward General Medical Center Cancer Center, Fort Lauderdale
Kaplan Cancer Center at St. Mary's Medical Center, West Palm Beach
St. Joseph's Cancer Institute at St. Joseph's Hospital, Tampa
All Children's Hospital, St. Petersburg
Lee Cancer Care of Lee Memorial Health System, Fort Myers
Lurleen Wallace Comprehensive Cancer at University of Alabama - Birmingham, Birmingham
T.C. Thompson Children's Hospital, Chattanooga
East Tennessee Children's Hospital, Knoxville
St. Jude Children's Research Hospital, Memphis
Kosair Children's Hospital, Louisville
Toledo Hospital, Toledo
Medical University of Ohio Cancer Center, Toledo
Cleveland Clinic Taussig Cancer Center, Cleveland
St. Vincent Indianapolis Hospital, Indianapolis
Hurley Medical Center, Flint
Breslin Cancer Center at Ingham Regional Medical Center, Lansing
Midwest Children's Cancer Center, Milwaukee
Marshfield Clinic - Marshfield Center, Marshfield
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis
University of Minnesota Cancer Center, Minneapolis
Mayo Clinic Cancer Center, Rochester
Advocate Christ Medical Center, Oak Lawn
Children's Memorial Hospital - Chicago, Chicago
Saint Jude Midwest Affiliate, Peoria
Siteman Cancer Center at Barnes-Jewish St. Peters Hospital - Saint Louis, St Louis
Children's Mercy Hospital, Kansas City
Children's Hospital of New Orleans, New Orleans
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences, Little Rock
Oklahoma University Cancer Institute, Oklahoma City
Medical City Dallas Hospital, Dallas
Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas, Dallas
Cook Children's Medical Center - Fort Worth, Fort Worth
CCOP - Scott and White Hospital, Temple
University of Texas Health Science Center at San Antonio, San Antonio
Driscoll Children's Hospital, Corpus Christi
Dell Children's Medical Center of Central Texas, Austin
Texas Tech University Health Sciences Center School of Medicine - Amarillo, Amarillo
Covenant Children's Hospital, Lubbock
Children's Hospital Center for Cancer and Blood Disorders, Aurora
Childrens Hospital Los Angeles, Los Angeles
Jonathan Jaques Children's Cancer Center at Miller Children's Hospital, Long Beach
Loma Linda University Cancer Institute at Loma Linda University Medical Center, Loma Linda
Children's Hospital of Orange County, Orange
UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco
Children's Hospital and Research Center Oakland, Oakland
Sutter Cancer Center, Sacramento
University of California Davis Cancer Center, Sacramento
Kaiser Permanente Medical Center - Oakland, Sacramento
Cancer Research Center of Hawaii, Honolulu
Children's Hospital and Regional Medical Center - Seattle, Seattle
Mary Bridge Children's Hospital and Health Center - Tacoma, Tacoma
Phoenix Children's Hospital, Phoenix
Arizona Cancer Center at University of Arizona Health Sciences Center, Tucson
Southern California Permanente Medical Group, Downey
Children's Hospital Central California, Madera
Rady Children's Hospital - San Diego, San Diego
Stanford Cancer Center, Stanford
Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center, Farmington
Children's National Medical Center, Washington D.C.
Walter Reed Army Medical Center, Washington D.C.
University of Florida Shands Cancer Center, Gainesville
Florida Hospital Cancer Institute at Florida Hospital Orlando, Orlando
MBCCOP - Medical College of Georgia Cancer Center, Augusta
Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center, Savannah
University of Illinois Cancer Center, Chicago
University of Chicago Cancer Research Center, Chicago
Advocate Lutheran General Cancer Care Center, Park Ridge
Simmons Cooper Cancer Institute, Springfield
Indiana University Melvin and Bren Simon Cancer Center, Indianapolis
Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center, Kansas City
Lucille P. Markey Cancer Center at University of Kentucky, Lexington
Tulane Cancer Center Office of Clinical Research, Alexandria
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore
Floating Hospital for Children at Tufts - New England Medical Center, Boston
Massachusetts General Hospital, Boston
Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute, Boston
C.S. Mott Children's Hospital at University of Michigan Medical Center, Ann Arbor
Barbara Ann Karmanos Cancer Institute, Detroit
Butterworth Hospital at Spectrum Health, Grand Rapids
CCOP - Kalamazoo, Kalamazoo
University of Mississippi Cancer Clinic, Jackson
Children's Hospital, Omaha
UNMC Eppley Cancer Center at the University of Nebraska Medical Center, Omaha
Sunrise Hospital and Medical Center, Las Vegas
Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center, Lebanon
Hackensack University Medical Center Cancer Center, Hackensack
Overlook Hospital, Morristown
Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School, New Brunswick
Newark Beth Israel Medical Center, Newark
St. Joseph's Hospital and Medical Center, Paterson
University of New Mexico Cancer Center, Albuquerque
Albany Medical Center Hospital, Albany
Roswell Park Cancer Institute, Buffalo
Stony Brook University Cancer Center, Stony Brook
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill, Chapel Hill
Blumenthal Cancer Center at Carolinas Medical Center, Charlotte
Presbyterian Cancer Center at Presbyterian Hospital, Charlotte
Wake Forest University Comprehensive Cancer Center, Winston-Salem
Akron Children's Hospital, Akron
Cincinnati Children's Hospital Medical Center, Cincinnati
Rainbow Babies and Children's Hospital, Cleveland
Nationwide Children's Hospital, Columbus
Children's Medical Center - Dayton, Dayton
Oregon Health and Science University Cancer Institute, Portland
Geisinger Cancer Institute at Geisinger Health, Danville
Penn State Cancer Institute at Milton S. Hershey Medical Center, Hershey
Children's Hospital of Philadelphia, Philadelphia
Sanford Cancer Center at Sanford USD Medical Center, Sioux Falls
Vanderbilt-Ingram Cancer Center, Nashville
Baylor University Medical Center - Houston, Houston
M. D. Anderson Cancer Center at University of Texas, Houston
Methodist Children's Hospital of South Texas, San Antonio
Primary Children's Medical Center, Salt Lake City
Fletcher Allen Health Care - University Health Center Campus, Burlington
Inova Fairfax Hospital, Falls Church
Children's Hospital of The King's Daughters, Norfolk
Providence Cancer Center at Sacred Heart Medical Center, Spokane
Alberta Children's Hospital, Calgary
University of Alberta Hospital, Edmonton
Children's & Women's Hospital of British Columbia, Vancouver
CancerCare Manitoba, Winnipeg
Janeway Children's Health and Rehabilitation Centre, St. John's
IWK Health Centre, Halifax
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton
Cancer Centre of Southeastern Ontario at Kingston General Hospital, Kingston
Children's Hospital of Western Ontario, London
Children's Hospital of Eastern Ontario, Ottawa
Hospital for Sick Children, Toronto
Montreal Children's Hospital at McGill University Health Center, Montreal
Hopital Sainte Justine, Montreal
Saskatoon Cancer Centre at the University of Saskatchewan, Saskatoon
Centre Hospitalier Universitaire de Quebec, Québec
San Jorge Children's Hospital, Santurce
National Cancer Institute (NCI)
NIH
Children's Oncology Group
NETWORK