NCT00353652 - Effects of Thiazide Diuretics on Sympathetic Nervous System in Hypertension | Biotech Hunter

Enrollment

166

Participants

Timeline

Start Date

January 31, 2005

Primary Completion Date

January 31, 2013

Study Completion Date

January 31, 2013

Conditions

Hypertension

Interventions

DRUG

Study#1: chlorthalidone (CTD), titrated dose

Participants in study #1 will receive 3 months of chlorthalidone (12.5-25 mg/d) at the dose titrated to achieve 24-h ambulatory BP \< 130/80 mmHg

DRUG

Study #1: spironolactone (SP), titrated dose

Participants in study #1 will receive 3 months spironolactone (25-75 mg/d), at the dose titrated to achieve 24-h ambulatory BP \< 130/80 mmHg.

DRUG

Study# 2 chlorthalidone (CTD), fixed dose

Participants in study #2 will receive 3 months of fixed-dose of CTD, at 25 mg/d.

DRUG

Study# 2 spironolactone (SP), fixed dose

Participants in study #2 will receive 3 months of fixed-dose SP at 25 mg daily.

DRUG

Study# 2 irbsesartan (IR), fixed dose

Participants in study #2 will receive 3 months of fixed-dose IR at150 mg daily.

Trial Locations (2)

University of Texas Southwestern Medical Center at Dallas, Dallas

University of Texas Southwestern Medical Center, Dallas

All Listed Sponsors

collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

lead

University of Texas Southwestern Medical Center

OTHER