Lenalidomide and Azacitidine in Treating Patients With Advanced Myelodysplastic Syndromes

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

37

Participants

Timeline

Start Date

May 31, 2006

Primary Completion Date

September 30, 2011

Study Completion Date

September 30, 2011

Conditions
LeukemiaMyelodysplastic Syndromes
Interventions
DRUG

azacitidine

Azacitidine subcutaneously once daily on days 1-5 or days 1-5 and 8-12. Treatment repeats every 28 days for up to 7 courses in the absence of relapse (after achieving complete or partial remission), disease progression, or unacceptable toxicity.

DRUG

lenalidomide

Oral lenalidomide once daily on days 1-14 or days 1-21.Treatment repeats every 28 days for up to 7 courses in the absence of relapse (after achieving complete or partial remission), disease progression, or unacceptable toxicity.

Trial Locations (3)

44195

Cleveland Clinic Taussig Cancer Instititute, Case Comprehensive Cancer Center, Cleveland

90095-1781

University of California at Los Angeles, Los Angeles

33612-9497

H. Lee Moffitt Cancer Center and Research Institute at University of South Florida, Tampa

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Mikkael Sekeres MD

OTHER

NCT00352001 - Lenalidomide and Azacitidine in Treating Patients With Advanced Myelodysplastic Syndromes | Biotech Hunter | Biotech Hunter