Single-Dose Intravenous Inositol Pharmacokinetics in Preterm Infants

PHASE2CompletedINTERVENTIONAL
Enrollment

74

Participants

Timeline

Start Date

June 30, 2006

Primary Completion Date

December 31, 2007

Study Completion Date

December 31, 2007

Conditions
Infant, NewbornInfant, Low Birth WeightInfant, Small for Gestational AgeInfant, PrematureRetinopathy of PrematurityBronchopulmonary Dysplasia (BPD)
Interventions
DRUG

Inositol lower volume

60 mg/kg (1.2ml/kg) of myo-inositol 5% given intravenously over 20 minutes.

DRUG

Inositol higher volume

120 mg/kg (2.4ml/kg) of myo-inositol 5% given intravenously over 20 minutes.

DRUG

Placebo lower volume

60 mg/kg (1.2ml/kg) of glucose 5% given intravenously over 20 minutes.

DRUG

Placebo higher volume

120 mg/kg (2.4ml/kg) of glucose 5% given intravenously over 20 minutes.

Trial Locations (11)

14642

University of Rochester, Rochester

27705

RTI International, Durham

27710

Duke University, Durham

44106

Case Western Reserve University, Rainbow Babies and Children's Hospital, Cleveland

46202

Indiana University, Indianapolis

48201

Wayne State University, Detroit

75235

University of Texas Southwestern Medical Center at Dallas, Dallas

84108

University of Utah, Salt Lake City

87131

University of New Mexico, Albuquerque

06504

Yale University, New Haven

02905

Brown University, Women & Infants Hospital of Rhode Island, Providence

All Listed Sponsors
collaborator

National Eye Institute (NEI)

NIH

collaborator

National Center for Research Resources (NCRR)

NIH

collaborator

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

NIH

lead

NICHD Neonatal Research Network

NETWORK

NCT00349726 - Single-Dose Intravenous Inositol Pharmacokinetics in Preterm Infants | Biotech Hunter | Biotech Hunter