90
Participants
Start Date
July 31, 2006
Primary Completion Date
February 28, 2010
Study Completion Date
February 28, 2010
Betaine
100-200 mg per kg per day by mouth with a maximum of 6 grams divided in two daily doses
Creatine
200 mg per kg per day with a daily maximum of 5 grams divided in two daily doses
Metafolin
0.5 mg per kg per day by mouth with a maximum of 8 milligrams divided in two daily doses
Vitamin B12
1 mg by mouth per day for all weights and ages
Rady Children's Hospital San Diego, San Diego
Children's Hospital Boston, Boston
Greenwood Genetics Center, Greenwood
Baylor College of Medicine, Houston
Baylor College of Medicine
OTHER
Rady Children's Hospital, San Diego
OTHER
Boston Children's Hospital
OTHER
Greenwood Genetic Center
OTHER
Rare Diseases Clinical Research Network
NETWORK
University of California, San Diego
OTHER