Combination Chemotherapy, Radiation Therapy, and/or Surgery in Treating Patients With High-Risk Kidney Tumors

PHASE2CompletedINTERVENTIONAL
Enrollment

291

Participants

Timeline

Start Date

June 30, 2006

Primary Completion Date

December 31, 2015

Conditions
Childhood Renal Cell CarcinomaClear Cell Renal Cell CarcinomaClear Cell Sarcoma of the KidneyPapillary Renal Cell CarcinomaRhabdoid Tumor of the KidneyStage I Renal Cell CancerStage I Renal Wilms TumorStage II Renal Cell CancerStage II Renal Wilms TumorStage III Renal Cell CancerStage III Renal Wilms TumorStage IV Renal Cell CancerStage IV Renal Wilms Tumor
Interventions
DRUG

Doxorubicin Hydrochloride

Given IV

DRUG

Irinotecan Hydrochloride

Given IV

PROCEDURE

Conventional Surgery

Patients undergo resection

DRUG

Cyclophosphamide

Given IV

DRUG

Etoposide

Given IV

DRUG

Carboplatin

Given IV

BIOLOGICAL

Dactinomycin

Given IV

DRUG

Vincristine Sulfate

Given IV

RADIATION

Radiation Therapy

Undergo radiotherapy

OTHER

Laboratory Biomarker Analysis

Correlative studies

Trial Locations (187)

1145

Starship Children's Hospital, Grafton

2031

Sydney Children's Hospital, Randwick

2145

The Children's Hospital at Westmead, Westmead

2310

John Hunter Children's Hospital, Hunter Regional Mail Centre

3052

Royal Children's Hospital, Parkville

4029

Royal Brisbane and Women's Hospital, Herston

Royal Children's Hospital-Brisbane, Herston

5006

Women's and Children's Hospital-Adelaide, North Adelaide

6008

Princess Margaret Hospital for Children, Perth

10016

New York University Langone Medical Center, New York

10032

Columbia University Medical Center, New York

10065

Memorial Sloan-Kettering Cancer Center, New York

Weill Medical College of Cornell University, New York

11040

The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park

11794

Stony Brook University Medical Center, Stony Brook

13210

State University of New York Upstate Medical University, Syracuse

14263

Roswell Park Cancer Institute, Buffalo

14642

University of Rochester, Rochester

15224

Children's Hospital of Pittsburgh of UPMC, Pittsburgh

17033

Penn State Hershey Children's Hospital, Hershey

17822

Geisinger Medical Center, Danville

18017

Lehigh Valley Hospital - Muhlenberg, Bethlehem

19104

Children's Hospital of Philadelphia, Philadelphia

19134

Saint Christopher's Hospital for Children, Philadelphia

19803

Alfred I duPont Hospital for Children, Wilmington

20010

Children's National Medical Center, Washington D.C.

20057

Lombardi Comprehensive Cancer Center at Georgetown University, Washington D.C.

21215

Sinai Hospital of Baltimore, Baltimore

21287

Johns Hopkins University/Sidney Kimmel Comprehensive Cancer Center, Baltimore

22042

Inova Fairfax Hospital, Falls Church

23298

Virginia Commonwealth University/Massey Cancer Center, Richmond

23507

Childrens Hospital-King's Daughters, Norfolk

24014

Carilion Clinic Children's Hospital, Roanoke

25304

West Virginia University Charleston, Charleston

27157

Wake Forest University Health Sciences, Winston-Salem

27599

University of North Carolina, Chapel Hill

27710

Duke University Medical Center, Durham

27858

East Carolina University, Greenville

28203

Carolinas Medical Center, Charlotte

28204

Novant Health Presbyterian Medical Center, Charlotte

28801

Mission Hospital-Memorial Campus, Asheville

29203

Palmetto Health Richland, Columbia

29605

BI-LO Charities Children's Cancer Center, Greenville

Greenville Cancer Treatment Center, Greenville

30322

Children's Healthcare of Atlanta - Egleston, Atlanta

31404

Memorial University Medical Center, Savannah

32207

Nemours Children's Clinic-Jacksonville South, Jacksonville

32504

Nemours Children's Clinic - Pensacola, Pensacola

32803

Florida Hospital Orlando, Orlando

32806

UF Cancer Center at Orlando Health, Orlando

33021

Memorial Healthcare System - Joe DiMaggio Children's Hospital, Hollywood

33136

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33155

Miami Children's Hospital, Miami

33176

Baptist Hospital of Miami, Miami

33316

Broward Health Medical Center, Fort Lauderdale

33407

Saint Mary's Hospital, West Palm Beach

33607

Saint Joseph Children's Hospital of Tampa, Tampa

33701

All Children's Hospital, St. Petersburg

33908

Golisano Children's Hospital of Southwest Florida, Fort Myers

35233

Children's Hospital of Alabama, Birmingham

University of Alabama at Birmingham, Birmingham

36604

University of South Alabama, Mobile

37232

Vanderbilt-Ingram Cancer Center, Nashville

37403

T C Thompson Children's Hospital, Chattanooga

37916

East Tennessee Childrens Hospital, Knoxville

38105

St. Jude Children's Research Hospital, Memphis

39216

University of Mississippi Medical Center, Jackson

40202

Kosair Children's Hospital, Louisville

40536

University of Kentucky/Markey Cancer Center, Lexington

43205

Nationwide Children's Hospital, Columbus

43606

The Toledo Hospital/Toledo Children's Hospital, Toledo

43608

Mercy Children's Hospital, Toledo

44106

Rainbow Babies and Childrens Hospital, Cleveland

44195

Cleveland Clinic Foundation, Cleveland

44308

Children's Hospital Medical Center of Akron, Akron

45229

Cincinnati Children's Hospital Medical Center, Cincinnati

45404

Dayton Children's Hospital, Dayton

46202

Riley Hospital for Children, Indianapolis

46260

Saint Vincent Hospital and Health Services, Indianapolis

48109

C S Mott Children's Hospital, Ann Arbor

48201

Wayne State University/Karmanos Cancer Institute, Detroit

48236

Saint John Hospital and Medical Center, Detroit

48502

Hurley Medical Center, Flint

49007

Bronson Methodist Hospital, Kalamazoo

49008

Kalamazoo Center for Medical Studies, Kalamazoo

49503

Helen DeVos Children's Hospital at Spectrum Health, Grand Rapids

50309

Blank Children's Hospital, Des Moines

52242

University of Iowa Hospitals and Clinics, Iowa City

53226

Midwest Children's Cancer Center, Milwaukee

53792

University of Wisconsin Hospital and Clinics, Madison

54449

Marshfield Clinic, Marshfield

55404

Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis

55905

Mayo Clinic, Rochester

60068

Advocate Lutheran General Hospital., Park Ridge

60153

Loyola University Medical Center, Maywood

60453

Advocate Children's Hospital-Oak Lawn, Oak Lawn

60611

Lurie Children's Hospital-Chicago, Chicago

60612

University of Illinois, Chicago

60637

University of Chicago Comprehensive Cancer Center, Chicago

61602

Saint Jude Midwest Affiliate, Peoria

62702

Southern Illinois University, Springfield

63104

Cardinal Glennon Children's Medical Center, St Louis

63110

Washington University School of Medicine, St Louis

63141

Saint John's Mercy Medical Center, St Louis

64108

The Childrens Mercy Hospital, Kansas City

68114

Children's Hospital and Medical Center of Omaha, Omaha

68198

University of Nebraska Medical Center, Omaha

70112

Tulane University Health Sciences Center, New Orleans

70118

Children's Hospital New Orleans, New Orleans

73104

University of Oklahoma Health Sciences Center, Oklahoma City

74136

Natalie Warren Bryant Cancer Center at Saint Francis, Tulsa

75230

Medical City Dallas Hospital, Dallas

75390

University of Texas Southwestern Medical Center, Dallas

76104

Cook Children's Medical Center, Fort Worth

76508

Scott and White Memorial Hospital, Temple

77030

Baylor College of Medicine, Houston

78229

Methodist Children's Hospital of South Texas, San Antonio

University of Texas Health Science Center at San Antonio, San Antonio

78411

Driscoll Children's Hospital, Corpus Christi

78723

Dell Children's Medical Center of Central Texas, Austin

79106

Texas Tech University Health Science Center-Amarillo, Amarillo

79410

Covenant Children's Hospital, Lubbock

80045

Children's Hospital Colorado, Aurora

80218

Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center, Denver

83712

Saint Luke's Mountain States Tumor Institute, Boise

84113

Primary Children's Hospital, Salt Lake City

85016

Phoenix Childrens Hospital, Phoenix

85724

University of Arizona Health Sciences Center, Tucson

87106

University of New Mexico Cancer Center, Albuquerque

University of New Mexico, Albuquerque

89106

Nevada Cancer Research Foundation CCOP, Las Vegas

90027

Children's Hospital Los Angeles, Los Angeles

90242

Southern California Permanente Medical Group, Downey

90806

Miller Children's Hospital, Long Beach

92123

Rady Children's Hospital - San Diego, San Diego

92354

Loma Linda University Medical Center, Loma Linda

92868

Childrens Hospital of Orange County, Orange

94143

University of California San Francisco Medical Center-Parnassus, San Francisco

94304

Lucile Packard Children's Hospital Stanford University, Palo Alto

94611

Kaiser Permanente-Oakland, Oakland

96813

University of Hawaii Cancer Center, Honolulu

96859

Tripler Army Medical Center, Honolulu

97227

Legacy Emanuel Children's Hospital, Portland

Legacy Emanuel Hospital and Health Center, Portland

98105

Seattle Children's Hospital, Seattle

98405

Mary Bridge Children's Hospital and Health Center, Tacoma

98431

Madigan Army Medical Center, Tacoma

99204

Providence Sacred Heart Medical Center and Children's Hospital, Spokane

72202-3591

Arkansas Children's Hospital, Little Rock

93636-8762

Children's Hospital Central California, Madera

94609-1809

Children's Hospital and Research Center at Oakland, Oakland

06106

Connecticut Children's Medical Center, Hartford

04401

Eastern Maine Medical Center, Bangor

04074

Maine Children's Cancer Program, Scarborough

20889-5600

Walter Reed National Military Medical Center, Bethesda

02114

Massachusetts General Hospital Cancer Center, Boston

02115

Dana-Farber Cancer Institute, Boston

01655

University of Massachusetts Medical School, Worcester

48824-7016

Michigan State University Clinical Center, East Lansing

03756

Dartmouth Hitchcock Medical Center, Lebanon

07601

Hackensack University Medical Center, Hackensack

07962

Morristown Memorial Hospital, Morristown

08903

UMDNJ - Robert Wood Johnson University Hospital, New Brunswick

07112

Newark Beth Israel Medical Center, Newark

07503

Saint Joseph's Regional Medical Center, Paterson

07902

Overlook Hospital, Summit

02903

Rhode Island Hospital, Providence

57117-5134

Sanford USD Medical Center - Sioux Falls, Sioux Falls

05405

University of Vermont College of Medicine, Burlington

23708-2197

Naval Medical Center - Portsmouth, Portsmouth

T3B 6A8

Alberta Children's Hospital, Calgary

T6G 2B7

University of Alberta Hospital, Edmonton

V6H 3V4

British Columbia Children's Hospital, Vancouver

R3E 0V9

CancerCare Manitoba, Winnipeg

A1B 3V6

Janeway Child Health Centre, St. John's

B3J 3G9

IWK Health Centre, Halifax

L8N 3Z5

McMaster Children's Hospital at Hamilton Health Sciences, Hamilton

L8S 4L8

Chedoke-McMaster Hospitals, Hamilton

K7L 5P9

Cancer Centre of Southeastern Ontario at Kingston General Hospital, Kingston

N6A 5W9

Children's Hospital, London

K1H 8L1

Children's Hospital of Eastern Ontario, Ottawa

M5G 1X8

Hospital for Sick Children, Toronto

H3H 1P3

The Montreal Children's Hospital of the MUHC, Montreal

H3T 1C5

Centre Hospitalier Universitaire Sainte-Justine, Montreal

G1V 4G2

Centre Hospitalier Universitaire de Quebec, Ste-Foy

S7N 4H4

Saskatoon Cancer Centre, Saskatoon

00912

San Jorge Children's Hospital, San Juan

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Children's Oncology Group

NETWORK

NCT00335556 - Combination Chemotherapy, Radiation Therapy, and/or Surgery in Treating Patients With High-Risk Kidney Tumors | Biotech Hunter | Biotech Hunter