109
Participants
Start Date
March 31, 2006
Primary Completion Date
November 30, 2014
Study Completion Date
November 30, 2014
Calcium
A single dose of 500 mg of elemental calcium orally each day for 3 years.
Zoledronic acid
Patients receive IV over 15 minutes once every 6 months for 3 years. The goal dose of zoledronic acid is 4 mg, but the selection of dose is determined based on calculated creatinine clearance at baseline.
radiation therapy
Patients must receive external beam irradiation, brachytherapy (HDR or LDR), or a combination of external beam irradiation and brachytherapy at the discretion of the treating physician. Dose/duration also will be at the discretion of the treating physician; however, dose will not exceed 45 Gy to 100% of the proximal femur, and no proximal femur will receive ≥ 60 Gy.
LHRH
LHRH therapy must take place for a minimum of one year. Choice of LHRH agonist, dose, and duration are at the discretion of the treating physician.
Vitamin D
400 IU (10μg), orally each day for 3 years.
Veterans Affairs Medical Center - Brooklyn, Brooklyn
CCOP - Hematology-Oncology Associates of Central New York, East Syracuse
Lourdes Regional Cancer Center, Binghamton
Adams Cancer Center, Gettysburg
York Cancer Center at Apple Hill Medical Center, York
Rosenfeld Cancer Center at Abington Memorial Hospital, Abington
Bryn Mawr Hospital, Bryn Mawr
Lankenau Cancer Center at Lankenau Hospital, Wynnewood
St. Agnes Hospital Cancer Center, Baltimore
Sentara Cancer Institute at Sentara Norfolk General Hospital, Norfolk
Wayne Radiation Oncology, Goldsboro
Cancer Centers of North Carolina - Raleigh, Raleigh
Wilmed Radiation Oncology Services, Wilson
Mission Hospitals - Memorial Campus, Asheville
Northeast Georgia Medical Center, Gainesville
Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center, Kingsport
McDowell Cancer Center at Akron General Medical Center, Akron
Cancer Research UK Medical Oncology Unit at Churchill Hospital & Weatherall Institute of Molecular Medicine - Oxford, Salem
Cancer Treatment Center, Wooster
Precision Radiotherapy at University Pointe, West Chester
Charles M. Barrett Cancer Center at University Hospital, Cincinnati
Methodist Cancer Center at Methodist Hospital, Indianapolis
Center for Cancer Care at Goshen General Hospital, Goshen
Josephine Ford Cancer Center at Henry Ford Hospital, Detroit
Community Memorial Hospital Cancer Care Center, Menomonee Falls
Vince Lombardi Cancer Clinic at Aurora St. Luke's Medical Center, Milwaukee
Medical College of Wisconsin Cancer Center, Milwaukee
West Allis Memorial Hospital, West Allis
Veterans Affairs Medical Center - Milwaukee, Milwaukee
Bay Area Cancer Care Center at Bay Area Medical Center, Marinette
Theda Care Cancer Institute, Appleton
CentraCare Clinic - River Campus, Saint Cloud
Coborn Cancer Center, Saint Cloud
CCOP - Montana Cancer Consortium, Billings
Northern Rockies Radiation Oncology Center, Billings
Great Falls Clinic - Main Facility, Great Falls
Northwest Community Hospital, Arlington Heights
Ingalls Cancer Care Center at Ingalls Memorial Hospital, Harvey
Saint James Hospital and Health Centers Comprehensive Cancer Institute - Olympia Fields, Olympia Fields
CCOP - Carle Cancer Center, Urbana
Saint Anthony's Hospital at Saint Anthony's Health Center, Alton
Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis, St Louis
CCOP - St. Louis-Cape Girardeau, St Louis
David C. Pratt Cancer Center at St. John's Mercy, St Louis
Southeast Missouri Regional Cancer Center at Southeast Missouri Hospital, Cape Girardeau
CCOP - Kansas City, Kansas City
St. John's Regional Health Center, Springfield
Hulston Cancer Center at Cox Medical Center South, Springfield
Penrose Cancer Center at Penrose Hospital, Colorado Springs
St. Mary - Corwin Regional Medical Center, Pueblo
LDS Hospital, Salt Lake City
Jon and Karen Huntsman Cancer Center at Intermountain Medical Center, Murray
Val and Ann Browning Cancer Center at McKay-Dee Hospital Center, Ogden
Utah Valley Regional Medical Center - Provo, Provo
Dixie Regional Medical Center - East Campus, St. George
University Medical Center of Southern Nevada, Las Vegas
CCOP - Nevada Cancer Research Foundation, Las Vegas
Renown Institute for Cancer at Renown Regional Medical Center, Reno
Robert and Beverly Lewis Family Cancer Care Center at Pomona Valley Hospital Medical Center, Pomona
Radiation Oncology Center - Roseville, Roseville
Radiological Associates of Sacramento Medical Group, Incorporated, Sacramento
Enloe Cancer Center at Enloe Medical Center, Chico
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital, Yakima
USC/Norris Comprehensive Cancer Center and Hospital, Los Angeles
Lucille P. Markey Cancer Center at University of Kentucky, Lexington
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore
Barbara Ann Karmanos Cancer Institute, Detroit
West Michigan Cancer Center, Kalamazoo
Kingsbury Center for Cancer Care at Cheshire Medical Center, Keene
Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center, Lebanon
Cancer Institute of New Jersey at Cooper University Hospital - Camden, Camden
Franklin & Edith Scarpa Regional Cancer Center at South Jersey Healthcare, Vineland
Cancer Institute of New Jersey at Cooper - Voorhees, Voorhees Township
Roswell Park Cancer Institute, Buffalo
Summa Center for Cancer Care at Akron City Hospital, Akron
Cancer Center of Paoli Memorial Hospital, Paoli
Fox Chase Cancer Center - Philadelphia, Philadelphia
Norris Cotton Cancer Center - North, Saint Johnsbury
Naval Medical Center - Portsmouth, Portsmouth
St. Vincent Hospital Regional Cancer Center, Green Bay
British Columbia Cancer Agency - Vancouver Island Centre, Victoria
Doctor H. Bliss Murphy Cancer Centre, St. John's
Margaret and Charles Juravinski Cancer Centre, Hamilton
Cancer Care Program at Thunder Bay Regional Health Sciences, Thunder Bay
Maisonneuve-Rosemont Hospital, Montreal
Centre Hospitalier Universitaire de Quebec, Québec
CHUS-Hopital Fleurimont, Sherbrooke
Allan Blair Cancer Centre at Pasqua Hospital, Regina
National Cancer Institute (NCI)
NIH
Radiation Therapy Oncology Group
NETWORK