Rituxan/BEAM vs Bexxar/BEAM in Autologous Hematopoietic Stem Cell Transplant for Non-Hodgkin's Lymphoma (BMTCTN0401)

PHASE3CompletedINTERVENTIONAL
Enrollment

224

Participants

Timeline

Start Date

December 31, 2005

Primary Completion Date

August 31, 2013

Study Completion Date

August 31, 2013

Conditions
Lymphoma, B-CellLymphoma, Large-Cell, ImmunoblasticLymphoma, Non-Hodgkin
Interventions
DRUG

Autologous transplantation using rituxan/BEAM

Rituxan 375 mg/m2 (Day -19 and Day -12); BCNU 300 mg/m2 (Day -6); Etoposide (VP-16) 100 mg/m2 twice a day (Days -5 to -2); Cytarabine 100 mg/m2 twice a day (Days -5 to -2); Melphalan 140 mg/m2 (Day -1); Followed by autologous transplantation

DRUG

Autologous transplantation using Bexxar/BEAM

Bexxar dosimetric dose 5 mCi (Day -19); Bexxar therapy dose 75 cGy TBD (Day -12); BCNU 300 mg/m2 (Day -6); Etoposide (VP-16) 100 mg/m2 twice a day (Days -5 to -2); Cytarabine 100 mg/m2 twice a day (Days -5 to -2); Melphalan 140 mg/m2 (Day -1); Followed by autologous transplantation

Trial Locations (36)

10021

Memorial Sloan-Kettering Cancer Center, New York

10065

Weill Cornell Medical College, The New York Presbyterian Hospital, New York

14642

University of Rochester Medical Center, Rochester

19104

University of Pennsylvania Cancer Center, Philadelphia

21228

University of Maryland Medical Systems/Greenbaum Cancer Center, Baltimore

21231

Johns Hopkins/SKCCC, Baltimore

23298

Virginia Commonwealth University/MCV Hospital, Richmond

27599

University of North Carolina Hospital at Chapel Hill, Chapel Hill

27705

Duke University Medical Center, Durham

29425

Medical University of South Carolina, Charleston

29615

Cancer Centers of the Carolinas, Greenville

30322

Emory University, Atlanta

32610

University of Florida College of Medicine (Shands), Gainesville

33136

University of Miami, Miami

33624

H. Lee Moffitt Cancer Center, Tampa

37232

Vanderbilt University Medical Center, Nashville

44106

University Hospitals of Cleveland/Case Western, Cleveland

48109

University of Michigan Medical Center, Ann Arbor

52242

University of Iowa Hospitals and Clinics, Iowa City

53211

Medical College of Wisconsin, Milwaukee

53792

University of Wisconsin Hospital and Clinics, Madison

55455

University of Minnesota, Minneapolis

60153

Loyola University Medical Center, Maywood

63110

Washington University/Barnes Jewish Hospital, St Louis

68198

University of Nebraska, Omaha

75246

Baylor University Medical Center, Dallas

78229

Texas Transplant Institute, San Antonio

83712

St. Lukes Mountain States Tumor Institute, Boise

84132

University of Utah Medical School, BMT, Salt Lake City

84143

Intermountain BMT Program, Salt Lake City

97213

Providence Portland Medical Center, Portland

97225

Columbia River Oncology Program, Portland

98109

Fred Hutchinson Cancer Research Center, Seattle

06520

Yale University School of Medicine, New Haven

02111

Tufts-New England Medical Center, Boston

07601

Hackensack University Medical Center, Hackensack

All Listed Sponsors
collaborator

Blood and Marrow Transplant Clinical Trials Network

NETWORK

collaborator

National Cancer Institute (NCI)

NIH

lead

National Heart, Lung, and Blood Institute (NHLBI)

NIH

NCT00329030 - Rituxan/BEAM vs Bexxar/BEAM in Autologous Hematopoietic Stem Cell Transplant for Non-Hodgkin's Lymphoma (BMTCTN0401) | Biotech Hunter | Biotech Hunter