10
Participants
Start Date
October 31, 2005
Primary Completion Date
July 31, 2009
Study Completion Date
June 30, 2011
Intensity-Modulated Radiotherapy (IMRT)
"The duration of radiation therapy will be total of 3 weeks. During the first week, all patients will be treated initially with whole brain radiation therapy (WBRT) at 2.5Gy per fraction daily 5 days a week to a dose of 12.5Gy. This will be delivered through parallel-opposed fields to cover the entire cranial contents.~For the remaining 2 weeks, patients will be treated using intensity-modulated radiation therapy (IMRT) technology such that a higher dose can be delivered to the tumor. IMRT is capable of generating complex 3-D dose distribution to conform closely to the target volume by modulating the radiation beam. This process is based on the inverse method of treatment planning to optimize radiation dose to tumor target coverage and normal tissue sparing."
Thomas Jefferson University, Philadelphia
Sidney Kimmel Cancer Center at Thomas Jefferson University
OTHER